Institute of Biochemistry and Biotechnology, Chung Shan Medical University, Taichung 402, Taiwan.
Plant Foods Hum Nutr. 2012 Sep;67(3):294-302. doi: 10.1007/s11130-012-0309-x.
Noni juice (NJ) is rich in phytochemicals and polysaccharides. Lipid-lowering and antioxidative effects of NJ were investigated in this study. Fifty male hamsters were assigned randomly to one of the following groups: (1) normal diet and distilled water (LFCD); (2) high-fat/cholesterol diet and distilled water (HFCD); (3) HFCD and 3 ml NJ (including 0.20 g solids)/kg BW (NJ_L); (4) HFCD and 6 mL NJ (including 0.40 g solids)/kg BW (NJ_M); (5) HFCD and 9 ml NJ (including 0.60 g solids)/kg BW (NJ_H) for six weeks. NJ supplementation decreased (p < 0.05) serum triacylglycerol, cholesterol, atherogenic index, malondialdehyde levels, and hepatic lipids in HFCD hamsters, whereas serum trolox equivalent antioxidant capacity, glutathione, and fecal lipids in HFCD hamsters were increased (p < 0.05) by NJ supplementation. Although NJ supplementation downregulated (p < 0.05) sterol regulator element binding protein-1c in HFCD hamsters, it upregulated (p < 0.05) hepatic peroxisome proliferator-activated receptor-alpha and uncoupling protein 2 gene expressions in HFCD hamsters. Results demonstrate that NJ promotes cardioprotection in a high-fat/cholesterol diet.
诺丽果汁（NJ）富含植物化学物质和多糖。本研究旨在探讨 NJ 的降脂和抗氧化作用。将 50 只雄性仓鼠随机分为以下 5 组：（1）正常饮食和蒸馏水（LFCD）；（2）高脂肪/胆固醇饮食和蒸馏水（HFCD）；（3）HFCD 和 3 ml NJ（含 0.20 g 固体）/kg BW（NJ_L）；（4）HFCD 和 6 ml NJ（含 0.40 g 固体）/kg BW（NJ_M）；（5）HFCD 和 9 ml NJ（含 0.60 g 固体）/kg BW（NJ_H），共 6 周。NJ 补充剂降低了 HFCD 仓鼠的血清三酰甘油、胆固醇、动脉粥样硬化指数、丙二醛水平和肝脂质（p<0.05），而 HFCD 仓鼠的血清 Trolox 当量抗氧化能力、谷胱甘肽和粪便脂质则增加（p<0.05）。尽管 NJ 补充剂下调了 HFCD 仓鼠的固醇调节元件结合蛋白-1c（p<0.05），但上调了 HFCD 仓鼠的肝过氧化物酶体增殖物激活受体-α和解偶联蛋白 2 基因表达（p<0.05）。结果表明，NJ 促进了高脂肪/胆固醇饮食的心脏保护作用。
