Domínguez-Avila J Abraham, González-Aguilar Gustavo A, Alvarez-Parrilla Emilio, de la Rosa Laura A
Coordinación de Tecnología de Alimentos de Origen Vegetal, Centro de Investigación en Alimentación y Desarrollo A. C., Carretera a La Victoria km 0.6, AP 1735, CP 83304 Hermosillo, Sonora, Mexico.
Departamento de Ciencias Químico-Biológicas, Instituto de Ciencias Biomédicas, Universidad Autónoma de Ciudad Juárez, Anillo Envolvente del PRONAF y Estocolmo s/n, CP 32310 Ciudad Juárez, Chihuahua, Mexico.
Int J Mol Sci. 2016 Jun 29;17(7):1002. doi: 10.3390/ijms17071002.
Peroxisome proliferator-activated receptors (PPAR) are transcription factors that modulate energy metabolism in liver, adipose tissue and muscle. High fat diets (HFD) can negatively impact PPAR expression or activity, favoring obesity, dyslipidemia, insulin resistance and other conditions. However, polyphenols (PP) found in vegetable foodstuffs are capable of positively modulating this pathway. We therefore focused this review on the possible effects that PP can have on PPAR when administered together with HFD. We found that PP from diverse sources, such as coffee, olives, rice, berries and others, are capable of inducing the expression of genes involved in a decrease of adipose mass, liver and serum lipids and lipid biosynthesis in animal and cell models of HFD. Since cells or gut bacteria can transform PP into different metabolites, it is possible that a synergistic or antagonistic effect ultimately occurs. PP molecules from vegetable sources are an interesting option to maintain or return to a state of energy homeostasis, possibly due to an adequate PPAR expression and activity.
过氧化物酶体增殖物激活受体（PPAR）是调节肝脏、脂肪组织和肌肉能量代谢的转录因子。高脂饮食（HFD）会对PPAR的表达或活性产生负面影响，从而导致肥胖、血脂异常、胰岛素抵抗和其他病症。然而，植物性食物中的多酚（PP）能够正向调节这一途径。因此，本综述聚焦于PP与HFD共同给药时对PPAR可能产生的影响。我们发现，来自咖啡、橄榄、大米、浆果等不同来源的PP，能够在HFD的动物和细胞模型中诱导参与减少脂肪量、肝脏和血清脂质以及脂质生物合成的基因表达。由于细胞或肠道细菌可将PP转化为不同的代谢产物，最终可能会产生协同或拮抗作用。植物来源的PP分子可能是维持或恢复能量稳态的一个有趣选择，这可能归因于PPAR的充分表达和活性。
