Limotai Chusak, Mirsattari Seyed M
Departments of Clinical Neurological Sciences, Medical Biophysics, Medical Imaging and Psychology, The University of Western Ontario, London, ON, Canada N6A 5A5.
Epilepsy Res Treat. 2012;2012:687219. doi: 10.1155/2012/687219. Epub 2012 May 15.
Many diagnostic tools have been employed to predict the likelihood of a postoperative memory decline after a standard temporal lobectomy, including the intracarotid amobarbital testing (IAT) or Wada, regarded as the gold standard test for over the past half a century. Functional MRI (fMRI) is also a promising tool in that regard. Its routine use to predict the postoperative memory decline has been limited because of the varied study paradigms, discrepancies in analysis, and interpretation of the results. Based on the existing literatures, fMRI cannot replace IAT for the routine presurgical evaluation of the patients with temporal lobe epilepsy (TLE) yet. Large multicentre studies with a panel of memory test are required to determine the full potential of fMRI and use it reliably to replace IAT in the routine clinical practice. In this paper, we review various aspects of memory fMRI, including the experimental designs, data analysis, and findings.
许多诊断工具已被用于预测标准颞叶切除术后记忆衰退的可能性，包括颈内动脉异戊巴比妥试验（IAT）或瓦达试验，在过去半个世纪里它被视为金标准测试。功能磁共振成像（fMRI）在这方面也是一种很有前景的工具。由于研究范式多样、分析差异以及结果解释不同，其用于预测术后记忆衰退的常规应用受到限制。基于现有文献，fMRI尚未能取代IAT用于颞叶癫痫（TLE）患者的常规术前评估。需要开展大量采用一系列记忆测试的多中心研究，以确定fMRI的全部潜力，并在常规临床实践中可靠地用其取代IAT。在本文中，我们综述了记忆fMRI的各个方面，包括实验设计、数据分析和研究结果。
