School of Dentistry, National Taiwan University, Taipei, Taiwan.
Oral Dis. 2013 May;19(4):381-6. doi: 10.1111/odi.12014. Epub 2012 Sep 7.
This study evaluated whether all the patients with serum gastric parietal cell antibody (GPCA) positivity had pernicious anemia (PA).
The blood hemoglobin (Hb), iron, and vitamin B12 concentrations, and mean corpuscular volume (MCV) in 124 GPCA-positive patients were measured and compared with the corresponding data in 124 age- and sex-matched healthy controls. PA was defined by World Health Organization (WHO) as having an Hb concentration < 13 g dl(-1) for men and < 12 g dl(-1) for women, an MCV ≥ 100 fl, and a serum vitamin B12 level < 200 pg ml(-1) .
We found that 20, 25, and 20 GPCA-positive patients had deficiencies of Hb (men < 13 g dl(-1) , women < 12 g dl(-1) ), iron (<60 μg dl(-1) ), and vitamin B12 (<200 pg ml(-1) ), respectively. Moreover, 16 GPCA-positive patients had abnormally high MCV (≥ 100 fl). GPCA-positive patients had a significantly higher frequency of Hb, iron, or vitamin B12 deficiency and of abnormally high MCV (all P-values < 0.001) than healthy controls. However, only 12.9% of 124 GPCA-positive patients were diagnosed as having PA by the WHO definition.
Only 12.9% of GPCA-positive patients are discovered to have PA by the WHO definition.
本研究旨在评估所有血清壁细胞抗体（GPCA）阳性患者是否均患有恶性贫血（PA）。
检测并比较了 124 例 GPCA 阳性患者的血液血红蛋白（Hb）、铁和维生素 B12 浓度以及平均红细胞体积（MCV），并与 124 例年龄和性别相匹配的健康对照者进行了比较。PA 按照世界卫生组织（WHO）的定义诊断为：男性 Hb 浓度＜13g/dl，女性 Hb 浓度＜12g/dl，MCV≥100fl，血清维生素 B12 水平＜200pg/ml。
我们发现，20、25 和 20 例 GPCA 阳性患者分别存在 Hb（男性＜13g/dl，女性＜12g/dl）、铁（＜60μg/dl）和维生素 B12（＜200pg/ml）缺乏，此外，16 例 GPCA 阳性患者的 MCV 异常升高（≥100fl）。GPCA 阳性患者的 Hb、铁或维生素 B12 缺乏以及 MCV 异常升高的频率明显高于健康对照者（均 P 值＜0.001）。然而，仅 12.9%的 124 例 GPCA 阳性患者按照 WHO 定义被诊断为患有 PA。
仅 12.9%的 GPCA 阳性患者按照 WHO 定义被发现患有 PA。
