Lee Yi-Pang, Jin Ying-Tai, Yu-Fong Chang Julia, Wang Yi-Ping, Sun Andy, Chiang Chun-Pin
Department of Dentistry, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.
Institute of Oral Medicine and Materials, College of Medicine, Tzu Chi University, Hualien, Taiwan.
J Dent Sci. 2025 Jul;20(3):1877-1884. doi: 10.1016/j.jds.2025.05.009. Epub 2025 May 22.
BACKGROUND/PURPOSE: Microcytosis is defined as having mean corpuscular volume (MCV) < 80 fL. This study evaluated whether 78 oral lichen planus (OLP) patients with microcytosis (microcytosis/OLP patients) and 510 OLP patients without microcytosis (non-microcytosis/OLP patients) had higher frequencies of anemia, hematinic deficiencies, hyperhomocysteinemia, and serum gastric parietal cell antibody (GPCA) positivity than 588 healthy control subjects.
Complete blood count and serum iron, vitamin B12, folic acid, homocysteine, and GPCA levels in 78 microcytosis/OLP patients, 510 non-microcytosis/OLP patients, and 588 healthy control subjects were measured and compared.
We found that 71.8 %, 46.2 %, 10.3 %, 0.0 %, 18.0 %, and 20.5 % of 78 microcytosis/OLP patients and 18.0 %, 12.4 %, 10.2 %, 1.4 %, 21.6 %, and 24.1 % of 510 non-microcytosis/OLP patients had blood hemoglobin, serum iron, vitamin B12, and folic acid deficiencies, hyperhomocysteinemia, and serum GPCA positivity, respectively. Both 78 microcytosis/OLP patients and 510 non-microcytosis/OLP patients had significantly higher frequencies of blood hemoglobin, serum iron and vitamin B12 deficiencies, hyperhomocysteinemia, and serum GPCA positivity than 588 healthy control subjects (all -values <0.001). Moreover, 78 microcytosis/OLP patients had significantly higher frequencies of blood hemoglobin and serum iron deficiencies than 510 non-microcytosis/OLP patients.
We conclude that our 78 microcytosis/OLP patients and 510 non-microcytosis/OLP patients have significantly higher frequencies of anemia, serum iron and vitamin B12 deficiencies, hyperhomocysteinemia, and serum GPCA positivity than 588 healthy control subjects. Moreover, 78 microcytosis/OLP patients also have significantly higher frequencies of blood hemoglobin and serum iron deficiencies than 510 non-microcytosis/OLP patients.
背景/目的：小红细胞症定义为平均红细胞体积（MCV）<80飞升。本研究评估了78例患有小红细胞症的口腔扁平苔藓（OLP）患者（小红细胞症/OLP患者）和510例无小红细胞症的OLP患者（非小红细胞症/OLP患者）是否比588名健康对照者有更高的贫血、造血物质缺乏、高同型半胱氨酸血症和血清胃壁细胞抗体（GPCA）阳性率。
对78例小红细胞症/OLP患者、510例非小红细胞症/OLP患者和588名健康对照者进行全血细胞计数，并检测血清铁、维生素B12、叶酸、同型半胱氨酸和GPCA水平，然后进行比较。
我们发现，78例小红细胞症/OLP患者中分别有71.8%、46.2%、10.3%、0.0%、18.0%和20.5%存在血红蛋白、血清铁、维生素B12和叶酸缺乏、高同型半胱氨酸血症以及血清GPCA阳性，510例非小红细胞症/OLP患者中分别有18.0%、12.4%、10.2%、1.4%、21.6%和24.1%存在上述情况。78例小红细胞症/OLP患者和510例非小红细胞症/OLP患者的血红蛋白、血清铁和维生素B12缺乏、高同型半胱氨酸血症以及血清GPCA阳性率均显著高于588名健康对照者（所有P值<0.001）。此外，78例小红细胞症/OLP患者的血红蛋白和血清铁缺乏率显著高于510例非小红细胞症/OLP患者。
我们得出结论，78例小红细胞症/OLP患者和510例非小红细胞症/OLP患者的贫血、血清铁和维生素B12缺乏、高同型半胱氨酸血症以及血清GPCA阳性率均显著高于588名健康对照者。此外，78例小红细胞症/OLP患者的血红蛋白和血清铁缺乏率也显著高于510例非小红细胞症/OLP患者。
