伴有或不伴有高同型半胱氨酸血症的扁平苔藓患者的贫血、造血物质缺乏及胃壁细胞抗体阳性情况。
Anemia, hematinic deficiencies, and gastric parietal cell antibody positivity in oral lichen planus patients with or without hyperhomocysteinemia.
作者信息
Lee Yi-Pang, Jin Ying-Tai, Yu-Fong Chang Julia, Wang Yi-Ping, Sun Andy, Chiang Chun-Pin
机构信息
Department of Dentistry, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.
Institute of Oral Medicine and Materials, College of Medicine, Tzu Chi University, Hualien, Taiwan.
出版信息
J Dent Sci. 2025 Jul;20(3):1802-1809. doi: 10.1016/j.jds.2025.05.004. Epub 2025 May 16.
BACKGROUND/PURPOSE: Our previous study found that 124 of 588 oral lichen planus (OLP) patients have hyperhomocysteinemia. This study assessed whether these 124 OLP patients with hyperhomocysteinemia (hyperhomocysteinemia/OLP patients) had significantly higher frequencies of anemia, hematinic deficiencies, and serum gastric parietal cell antibody (GPCA) positivity than 464 OLP patients without hyperhomocysteinemia (non-hyperhomocysteinemia/OLP patients) or 588 healthy control subjects.
MATERIALS AND METHODS
The blood hemoglobin (Hb) and serum iron, vitamin B12, folic acid, homocysteine, and GPCA levels in 124 hyperhomocysteinemia/OLP patients, 464 non-hyperhomocysteinemia/OLP patients, and 588 healthy control subjects were measured and compared.
RESULTS
We found that 124 hyperhomocysteinemia/OLP patients had significantly higher frequencies of macrocytosis, blood Hb and serum iron and vitamin B12 deficiencies, and serum GPCA positivity than 588 healthy control subjects (all -values <0.001) or 464 non-hyperhomocysteinemia/OLP patients (all -values <0.001). Anemia was found in 58 of 124 hyperhomocysteinemia/OLP patients and in 90 of 464 non-hyperhomocysteinemia/OLP patients. Normocytic anemia (22 cases), pernicious anemia (17 cases), and iron deficiency anemia (10 cases) were the three most common types of anemia in 124 hyperhomocysteinemia/OLP patients. Moreover, normocytic anemia (46 cases), iron deficiency anemia (22 cases), and thalassemia trait-induced anemia (18 cases) were the three most common types of anemia in 464 non-hyperhomocysteinemia/OLP patients. Moreover, the 124 hyperhomocysteinemia/OLP patients had significantly higher frequencies of macrocytic and normocytic anemia than the 464 non-hyperhomocysteinemia/OLP patients.
CONCLUSION
Hyperhomocysteinemia/OLP patients had significantly higher frequencies of macrocytosis, anemia, serum iron and vitamin B12 deficiencies, and serum GPCA positivity than healthy control subjects or non-hyperhomocysteinemia/OLP patients.
背景/目的：我们之前的研究发现，588例口腔扁平苔藓（OLP）患者中有124例患有高同型半胱氨酸血症。本研究评估了这124例患有高同型半胱氨酸血症的OLP患者（高同型半胱氨酸血症/OLP患者）与464例未患高同型半胱氨酸血症的OLP患者（非高同型半胱氨酸血症/OLP患者）或588例健康对照者相比，贫血、造血物质缺乏及血清胃壁细胞抗体（GPCA）阳性率是否显著更高。
材料与方法
检测并比较了124例高同型半胱氨酸血症/OLP患者、464例非高同型半胱氨酸血症/OLP患者及588例健康对照者的血红蛋白（Hb）、血清铁、维生素B12、叶酸、同型半胱氨酸及GPCA水平。
结果
我们发现，124例高同型半胱氨酸血症/OLP患者与588例健康对照者（所有P值<0.001）或464例非高同型半胱氨酸血症/OLP患者（所有P值<0.001）相比，大细胞性贫血、血液Hb及血清铁和维生素B12缺乏以及血清GPCA阳性率显著更高。124例高同型半胱氨酸血症/OLP患者中有58例发生贫血，464例非高同型半胱氨酸血症/OLP患者中有90例发生贫血。124例高同型半胱氨酸血症/OLP患者中最常见的三种贫血类型为正细胞性贫血（22例）、恶性贫血（17例）和缺铁性贫血（10例）。此外，464例非高同型半胱氨酸血症/OLP患者中最常见的三种贫血类型为正细胞性贫血（46例）、缺铁性贫血（22例）和地中海贫血性状所致贫血（18例）。而且，124例高同型半胱氨酸血症/OLP患者的大细胞性贫血和正细胞性贫血发生率显著高于464例非高同型半胱氨酸血症/OLP患者。
结论
高同型半胱氨酸血症/OLP患者与健康对照者或非高同型半胱氨酸血症/OLP患者相比，大细胞性贫血、贫血、血清铁和维生素B12缺乏以及血清GPCA阳性率显著更高。
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