与老年萎缩性舌炎患者相比，年轻萎缩性舌炎患者的血清维生素B12和叶酸平均水平显著降低，血清缺铁频率显著更高。
Significantly lower mean serum vitamin B12 and folic acid levels and a significantly higher frequency of serum iron deficiency in younger than in older atrophic glossitis patients.
作者信息
Wu Yu-Hsueh, Wu Yang-Che, Yu-Fong Chang Julia, Lee Yi-Pang, Chiang Chun-Pin, Sun Andy
机构信息
Department of Stomatology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Institute of Oral Medicine, School of Dentistry, National Cheng Kung University, Tainan, Taiwan.
出版信息
J Dent Sci. 2022 Oct;17(4):1487-1493. doi: 10.1016/j.jds.2022.05.023. Epub 2022 Jun 11.
BACKGROUND/PURPOSE: : Our previous study found that 19.0%, 16.9%, 5.3%, 2.3%, and 11.9% of 1064 atrophic glossitis (AG) patients have anemia, serum iron, vitamin B12, and folic acid deficiencies, and hyperhomocysteinemia, respectively. This study mainly evaluated the anemia, hematinic deficiencies, and hyperhomocysteinemia in 224 younger (≤50 years old) and 840 older (>50 years old) AG patients.
MATERIALS AND METHODS
The blood hemoglobin (Hb) and serum iron, vitamin B12, folic acid, and homocysteine levels in 224 younger and 840 older AG patients were measured and compared with the corresponding levels in 112 younger (≤50 years old) and 420 older (>50 years old) healthy control subjects (HCSs), respectively.
RESULTS
We found that 224 younger AG patients had significantly lower mean blood Hb and serum iron levels than 112 younger HCSs. Moreover, 840 older AG patients had significantly lower mean blood Hb and serum iron levels and a significantly higher mean serum homocysteine level than 420 older HCSs. In addition, 224 younger AG patients had significantly lower mean serum vitamin B12 and folic acid levels, a lower mean serum homocysteine level (marginal significance, = 0.056), a significantly higher frequency of serum iron deficiency, and a significantly lower frequency of hyperhomocysteinemia than 840 older AG patients.
CONCLUSION
The younger AG patients do have significantly lower mean serum vitamin B12 and folic acid levels, a significantly higher frequency of serum iron deficiency, and a significantly lower frequency of hyperhomocysteinemia than the older AG patients.
背景/目的：我们之前的研究发现，1064例萎缩性舌炎（AG）患者中，分别有19.0%、16.9%、5.3%、2.3%和11.9%患有贫血、血清铁缺乏、维生素B12缺乏、叶酸缺乏和高同型半胱氨酸血症。本研究主要评估了224例较年轻（≤50岁）和840例较年长（>50岁）AG患者的贫血、造血物质缺乏和高同型半胱氨酸血症情况。
材料与方法
检测了224例较年轻和840例较年长AG患者的血红蛋白（Hb）、血清铁、维生素B12、叶酸和同型半胱氨酸水平，并分别与112例较年轻（≤50岁）和420例较年长（>50岁）健康对照者（HCS）的相应水平进行比较。
结果
我们发现，224例较年轻AG患者的平均血液Hb和血清铁水平显著低于112例较年轻HCS。此外，840例较年长AG患者的平均血液Hb和血清铁水平显著低于420例较年长HCS，且平均血清同型半胱氨酸水平显著更高。此外，224例较年轻AG患者的平均血清维生素B12和叶酸水平显著更低，平均血清同型半胱氨酸水平更低（边缘显著性，P = 0.056），血清铁缺乏的频率显著更高，高同型半胱氨酸血症的频率显著低于840例较年长AG患者。
结论
较年轻AG患者的平均血清维生素B12和叶酸水平显著更低，血清铁缺乏的频率显著更高，高同型半胱氨酸血症 的频率显著低于较年长AG患者。
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