Abul Yasin, Karakurt Sait, Bostanci Korkut, Yuksel Mustafa, Eryuksel Emel, Evman Serdar, Celikel Turgay
Ministry of Health Bismil Government Hospital, Pulmonary Medicine Clinics, Diyarbakir, Turkey.
Multidiscip Respir Med. 2011 Feb 28;6(1):16-9. doi: 10.1186/2049-6958-6-1-16.
Although links between meteorological conditions and spontaneous pneumothorax (SP) have been proposed, the reports are controversial. In this study ozone levels, which are known to have some adverse effects on lung tissues, were investigated as a potential triggering factor of SP. At present there is not sufficient information about the effects of ozone on SP.
Of a total 79 pneumothorax patients recruited for the study, 21 secondary pneumothorax cases were excluded. In the remaining 58 SP patients, meteorological data at the time of SP occurrence were recorded.
The number of SP patients was higher in spring than in the other seasons (p < 0.05). There was an association between the SP frequency and the average ozone level at different seasons (F 3,52 = 19.45, p = 0.001). The average ozone level was higher in spring (363 ± 25 Dobson) than during the other seasons (autumn 296 ± 18 Dobson; summer 321 ± 26 Dobson; winter 324 ± 32 Dobson) (p = 0.001). There was a positive correlation between SP frequency and the average ozone values for each season (r = 0.301, p = 0.024). There was no significant correlation between the severity of SP and ozone level (r = 0.236, p = 0.16).
The number of SP patients increases in spring when ozone levels are highest. Ozone is known to affect alveolar cells and cause interstitial edema. Ozone causes damage to the lung interstitium by way of oxidative stress. Rupture of unrecognized underlying blebs/bullae has been proposed as a cause of SP. Increased levels of ozone may be a triggering factor for these ruptures.
尽管已有研究提出气象条件与自发性气胸（SP）之间存在联系，但相关报道存在争议。在本研究中，臭氧水平作为SP的一个潜在触发因素进行了调查，已知臭氧对肺组织有一些不良影响。目前关于臭氧对SP影响的信息尚不充分。
在总共招募的79例气胸患者中，排除了21例继发性气胸病例。在其余58例SP患者中，记录了SP发生时的气象数据。
春季SP患者数量高于其他季节（p < 0.05）。不同季节的SP发生率与平均臭氧水平之间存在关联（F 3,52 = 19.45，p = 0.001）。春季平均臭氧水平（363 ± 25多布森单位）高于其他季节（秋季296 ± 18多布森单位；夏季321 ± 26多布森单位；冬季324 ± 32多布森单位）（p = 0.001）。每个季节的SP发生率与平均臭氧值之间存在正相关（r = 0.301，p = 0.024）。SP的严重程度与臭氧水平之间无显著相关性（r = 0.236，p = 0.16）。
在臭氧水平最高的春季，SP患者数量增加。已知臭氧会影响肺泡细胞并导致间质水肿。臭氧通过氧化应激对肺间质造成损伤。未被识别的潜在肺大疱/肺泡破裂被认为是SP的一个原因。臭氧水平升高可能是这些破裂的触发因素。
