Université de Montréal, Department of Medicine, ECOGENE-21 Clinical Research Center; Chicoutimi Hospital, 305 St-Vallier Street, Chicoutimi (Québec), Saguenay, Canada.
BMC Oral Health. 2012 Sep 8;12:40. doi: 10.1186/1472-6831-12-40.
The salivary flow rate is an important determinant of salivary pH. It is influenced by several metabolic syndrome (MetS) components as well as the menopausal status. The cluster of cardiometabolic risk factors that characterizes the MetS could be exacerbated following menopause. The objective of this study was therefore to document the association between salivary pH and MetS expression in women according to the menopausal status.
In this cross-sectional study, unstimulated saliva collection was performed on 198 Caucasian women of French-Canadian origin of which 55 were premenopausal women (PMW) and 143 menopausal women (MW). Student's t test, ANOVA and correlation analyses were used to assess the association between salivary pH and MetS components.
The salivary pH level was significantly correlated with several MetS covariates, namely triglycerides (TG), apolipoprotein B (apo B) and plasma glucose concentrations as well as waist circumference and the number of MetS components present in the whole sample and PMW only. Mean pH levels decreased as the number of MetS components increased (p = 0.004). The correlations between salivary pH and variables associated with MetS components tended to be stronger in PMW. The proportion of the variance (R2) of salivary pH explained by MetS-related variables in PMW, MW and the whole sample was 23.6% (p = 0.041), 18.1% and 17.0% (p < 0.001) respectively.
The increasing prevalence of obesity calls for the development of new technologies to more easily monitor health status without increasing the burden of healthcare costs. As such, the salivary pH could be an inexpensive screening tool. These exploratory data suggest that salivary pH may be a significant correlate of the expression of MetS components. However, other studies with different populations are needed to confirm these findings before our observations lead to practical use in clinical settings.
唾液流量是唾液 pH 值的重要决定因素。它受到几种代谢综合征 (MetS) 成分以及绝经期状态的影响。代谢综合征的特征是心血管代谢风险因素的聚集，这种聚集可能会在绝经后加剧。因此，本研究的目的是根据绝经期状态记录唾液 pH 值与 MetS 表达之间的关系。
在这项横断面研究中，对 198 名具有法国-加拿大血统的白种女性进行了非刺激性唾液采集，其中 55 名为绝经前女性（PMW），143 名为绝经后女性（MW）。使用学生 t 检验、方差分析和相关分析来评估唾液 pH 值与 MetS 成分之间的关系。
唾液 pH 值水平与 MetS 多个协变量显著相关，即甘油三酯 (TG)、载脂蛋白 B (apo B) 和血浆葡萄糖浓度以及腰围和整个样本和 PMW 中存在的 MetS 成分数量。随着 MetS 成分数量的增加，平均 pH 值水平降低（p = 0.004）。唾液 pH 值与与 MetS 成分相关的变量之间的相关性在 PMW 中更强。在 PMW、MW 和整个样本中，MetS 相关变量解释的唾液 pH 值的方差比例 (R2) 分别为 23.6%（p = 0.041）、18.1%和 17.0%（p<0.001）。
肥胖症的患病率不断增加，需要开发新技术来更轻松地监测健康状况，而不会增加医疗保健成本的负担。因此，唾液 pH 值可能是一种廉价的筛查工具。这些探索性数据表明，唾液 pH 值可能是 MetS 成分表达的重要相关因素。然而，需要在不同人群中进行其他研究来证实这些发现，然后我们的观察结果才能在临床环境中实际应用。
