Department of Dentistry and Oral Surgery, Shinshu University School of Medicine, Matsumoto, Japan.
Medicine (Baltimore). 2020 Dec 18;99(51):e23688. doi: 10.1097/MD.0000000000023688.
Saliva tests, which are easy to perform and non-invasive, can be used to monitor both oral disease (especially periodontal disease) and physical conditions, including metabolic syndrome (MetS). Therefore, in the present study the associations between saliva test results and MetS were investigated based on medical health check-up data for a large population. In total, 1,888 and 2,296 individuals underwent medical check-ups for MetS and simultaneous saliva tests in 2017 and 2018, respectively. In the saliva tests, the buffer capacity of saliva, salivary pH, the salivary white blood cell count, the number of cariogenic bacteria in saliva, salivary occult blood, protein, and ammonia levels were tested using a commercially available kit. The relationships between the results of the saliva tests and MetS components were examined in cross-sectional and longitudinal multivariate analyses. Significant relationships were detected between salivary protein levels and serum HbA1c levels or blood pressure levels and between the buffer capacity of saliva and serum triglyceride levels. In addition, salivary pH was increased irreversibly by impaired renal function. This study suggested that saliva tests conducted during health check-ups of large populations might be a useful screening tool for periodontal disease and MetS/MetS components.
唾液检测简单易行且无创，可用于监测口腔疾病（尤其是牙周病）和包括代谢综合征（MetS）在内的身体状况。因此，本研究基于大规模人群的健康检查数据，探讨了唾液检测结果与 MetS 的相关性。2017 年和 2018 年，分别有 1888 名和 2296 名个体接受了 MetS 医疗检查和同时进行的唾液检测。在唾液检测中，使用市售试剂盒检测唾液的缓冲能力、唾液 pH 值、唾液白细胞计数、唾液致龋菌数量、唾液潜血、蛋白质和氨水平。采用横断面和纵向多元分析方法，检验唾液检测结果与 MetS 成分之间的关系。唾液蛋白水平与血清 HbA1c 水平或血压水平之间，唾液缓冲能力与血清甘油三酯水平之间存在显著相关性。此外，肾功能受损会使唾液 pH 值不可逆地升高。本研究提示，在大规模人群健康检查中进行唾液检测可能是牙周病和 MetS/MetS 成分的一种有用的筛查工具。
