突触能量的利用和供应。

Synaptic energy use and supply.

机构信息

Department of Neuroscience, Physiology & Pharmacology, University College London, Gower Street, London WC1E 6BT, UK.

出版信息

Neuron. 2012 Sep 6;75(5):762-77. doi: 10.1016/j.neuron.2012.08.019.

DOI:10.1016/j.neuron.2012.08.019

Abstract

Neuronal computation is energetically expensive. Consequently, the brain's limited energy supply imposes constraints on its information processing capability. Most brain energy is used on synaptic transmission, making it important to understand how energy is provided to and used by synapses. We describe how information transmission through presynaptic terminals and postsynaptic spines is related to their energy consumption, assess which mechanisms normally ensure an adequate supply of ATP to these structures, consider the influence of synaptic plasticity and changing brain state on synaptic energy use, and explain how disruption of the energy supply to synapses leads to neuropathology.

摘要

神经元计算需要消耗大量能量。因此，大脑有限的能量供应限制了其信息处理能力。大脑的大部分能量用于突触传递，因此了解能量如何供给和消耗突触就显得尤为重要。我们描述了信息如何通过突触前末梢和突触后棘传递与它们的能量消耗有关，评估了哪些机制通常能确保这些结构有足够的 ATP 供应，考虑了突触可塑性和大脑状态变化对突触能量利用的影响，并解释了突触能量供应中断如何导致神经病理学。