King's College London Dental Institute, London, United Kingdom.
Oral Surg Oral Med Oral Pathol Oral Radiol. 2012 Nov;114(5):597-603. doi: 10.1016/j.oooo.2012.05.009. Epub 2012 Sep 7.
The aim of this study was to develop a clinical oral dryness score (CODS) for routine use in assessment of xerostomia patients and determine its relationship with salivary flow rates and mucosal wetness.
CODS was determined from 10 features of oral dryness, each scoring as 1 point for a total score of 0-10. CODS, salivary flow rates, and mucosal wetness were measured in 100 patients and 50 healthy control subjects. The reproducibility of CODS was 0.89-0.96 (intraclass correlation coefficient).
The mean ± SD CODS in patients was 6.0 ± 1.6 compared with 1.0 ± 0.9 for control subjects (P < .001), and the highest mean value was in the primary Sjögren syndrome group. There was a general inverse relationship in patients between mean CODS and salivary flow rate (P < .01) and mean CODS and mucosal wetness (P < .01).
The CODS was found to be useful, easy to use, and reliable for routine assessment of the severity of dry mouth.
本研究旨在开发一种临床口腔干燥评分（CODS），以便常规用于评估口干症患者，并确定其与唾液流量和黏膜湿润度的关系。
CODS 由口腔干燥的 10 个特征确定，每个特征得分为 1 分，总分为 0-10 分。在 100 名患者和 50 名健康对照者中测量 CODS、唾液流量和黏膜湿润度。CODS 的重现性为 0.89-0.96（组内相关系数）。
患者的平均 ± SD CODS 为 6.0 ± 1.6，而对照组为 1.0 ± 0.9（P <.001），且原发性干燥综合征组的平均 CODS 值最高。患者的平均 CODS 与唾液流量（P <.01）和平均 CODS 与黏膜湿润度（P <.01）之间存在普遍的负相关关系。
CODS 被发现对于常规评估口干症的严重程度是有用、易用和可靠的。
