Jager Derk H Jan, Bots Casper P, Forouzanfar Tim, Brand Henk S
Department of Maxillofacial Surgery and Oral Pathology, VU University Medical Center, Amsterdam Movement Sciences, Boelelaan 1118, PO Box 7057, 1007 MB, Amsterdam, The Netherlands.
Department of Oral Health Sciences, KU Leuven & University Hospitals Leuven, Kapucijnenvoer 7, 3000, Leuven, Belgium.
Odontology. 2018 Oct;106(4):439-444. doi: 10.1007/s10266-018-0339-4. Epub 2018 Jan 22.
The purpose of this study was to explore the association of the clinical oral dryness score (CODS) with salivary flow rates, xerostomia inventory (XI), and bother index (BI). 147 patients were screened using CODS, which determined 10 features of oral dryness. Each feature contributed 1 point, and the total score varied from 0 to 10. Unstimulated (UWS), chewing-stimulated (CH-SWS) and acid-stimulated (A-SWS) whole salivary flows and the XI and BI were measured. Associations were explored with a bootstrapped Spearman rank correlation test (1000 × bootstrapping). Based on unstimulated salivary flow, 55 patients were classified as hyposalivators, 31 as low salivators, 48 as normosalivators and 13 as high salivators. Median CODS in the hyposalivation group was 5 (IQR 3-6) compared with 3 (IQR 2-5) in the low salivation group, 2 (IQR 1-4) in the normal salivation group and 2 (IQR 1-2.5) in the high salivation group. Significant associations between CODS and the other parameters were only found in the hyposalivation group between CODS and UWS (ρ(53) = - 0.513; p < 0.01), between CODS and CH-SWS (ρ(53) = - 0.453; p < 0.01), between CODS and A-SWS (ρ(53) = - 0.500; p < 0.01), CODS and XI (ρ(53) = 0.343; p < 0.001) and between CODS and BI (ρ(53) = 0.375; p = 0.01). In patients with hyposalivation, CODS is associated with unstimulated and stimulated salivary flow and XI and BI. CODS alone or a combination of CODS with a subjective measure, such as the XI or BI, could be recommended during routine clinical assessment to detect hyposalivation.
本研究的目的是探讨临床口腔干燥评分（CODS）与唾液流速、口干症量表（XI）及困扰指数（BI）之间的关联。使用CODS对147例患者进行筛查，该评分确定了10项口腔干燥特征。每项特征计1分，总分范围为0至10分。测量了非刺激性（UWS）、咀嚼刺激性（CH-SWS）和酸刺激性（A-SWS）全唾液流速以及XI和BI。采用自抽样Spearman等级相关检验（1000次自抽样）探索关联。根据非刺激性唾液流速，55例患者被分类为唾液分泌减少者，31例为低唾液分泌者，48例为正常唾液分泌者，13例为高唾液分泌者。唾液分泌减少组的CODS中位数为5（四分位间距3 - 6），低唾液分泌组为3（四分位间距2 - 5），正常唾液分泌组为2（四分位间距1 - 4），高唾液分泌组为2（四分位间距1 - 2.5）。仅在唾液分泌减少组中发现CODS与其他参数之间存在显著关联，即CODS与UWS之间（ρ(53) = - 0.513；p < 0.01）、CODS与CH-SWS之间（ρ(53) = - 0.453；p < 0.01）、CODS与A-SWS之间（ρ(53) = - 0.500；p < 0.01）、CODS与XI之间（ρ(53) = 0.343；p < 0.001）以及CODS与BI之间（ρ(53) = 0.375；p = 0.01）。在唾液分泌减少的患者中，CODS与非刺激性和刺激性唾液流速以及XI和BI相关。在常规临床评估期间，可推荐单独使用CODS或CODS与主观测量指标（如XI或BI）联合使用来检测唾液分泌减少。
