在餐后期间，增加血浆中左旋精氨酸的含量会降低老年人的餐后血脂。

Increased plasma availability of L-arginine in the postprandial period decreases the postprandial lipemia in older adults.

机构信息

Center for Metabolic and Vascular Biology, Arizona State University/Mayo Clinic Arizona, Scottsdale, Arizona, USA.

出版信息

Nutrition. 2013 Jan;29(1):81-8. doi: 10.1016/j.nut.2012.04.010. Epub 2012 Sep 6.

DOI:10.1016/j.nut.2012.04.010

PMID:22959634

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3519962/

Abstract

OBJECTIVE

Older adults have exaggerated postprandial lipemia, which increases their risk for cardiovascular disease. We sought to determine the effects of increased plasma L-arginine (L-ARG) availability on the oxidation of ingested fat (enriched with [1,1,1-(13)C]-triolein) and plasma triacylglycerol (TG) concentrations during the postprandial period in older subjects.

METHODS

On one day, eight healthy subjects (67.8 ± 1.3 y old) received an intravenous infusion of L-ARG during the first hour of the postprandial period (L-ARG trial), while on a separate day, and in a randomized order, they received saline (control trial).

RESULTS

The 8-h area under the plasma concentration-time curve describing the postprandial plasma TG concentrations was considerably lower in the L-ARG trial than in the control trial (-4 ± 21 versus 104 ± 21 mg ∙ dL(-1) ∙ h(-1), P < 0.01). The rate of the postprandial oxidation of the ingested lipid was not different between the trials, but the average contribution of the ingested oleate to the oleate of the TG of the plasma small TG-rich lipoproteins (Svedberg flotation index 20-400) was lower in the L-ARG trial (11 ± 1 versus 18 ± 2%, P < 0.01). L-ARG infusion also decreased the 8-h area under the plasma concentration-time curve of the plasma free fatty acid concentrations derived from the ingested fat compared with the saline infusion (0.77 ± 0.09 versus 1.11 ± 0.08; mmol ∙ L(-1) ∙ h(-1), P < 0.01).

CONCLUSION

Increasing the plasma L-ARG availability during the postprandial period decreases the postprandial lipemia in older adults, in association with a decrease in the postprandial contribution of ingested lipids into TGs of the plasma small TG-rich lipoproteins.

摘要

目的

老年人餐后血脂过度增加，使他们患心血管疾病的风险增加。我们旨在确定增加血浆 L-精氨酸（L-ARG）供应对老年人餐后期间摄入脂肪（用 [1,1,1-(13)C]-三油酸甘油酯标记）的氧化和血浆三酰甘油（TG）浓度的影响。

方法

在一天中，8 名健康受试者（67.8 ± 1.3 岁）在餐后的第一小时内接受 L-ARG 静脉输注（L-ARG 试验），而在另一天，以随机顺序，他们接受盐水（对照试验）。

结果

L-ARG 试验中 8 小时的餐后血浆 TG 浓度时间曲线下面积明显低于对照试验（-4 ± 21 与 104 ± 21 mg·dL(-1)·h(-1)，P < 0.01）。两个试验之间餐后摄入脂质的氧化率没有差异，但 L-ARG 试验中摄入的油酸在血浆小 TG 富含脂蛋白（Svedberg 漂浮指数 20-400）的 TG 中的比例较低（11 ± 1 与 18 ± 2%，P < 0.01）。与盐水输注相比，L-ARG 输注还降低了源自摄入脂肪的血浆游离脂肪酸浓度的 8 小时血浆浓度时间曲线下面积（0.77 ± 0.09 与 1.11 ± 0.08；mmol·L(-1)·h(-1)，P < 0.01）。