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血卟啉单甲醚(HMME)的光学性质,一种 PDT 光敏剂。

Optical properties of hematoporphyrin monomethyl ether (HMME), a PDT photosensitizer.

机构信息

Department of Electrical Engineering, Colorado Advanced Photonics Technology (CAPT) Laboratory, University of Colorado Denver, CO, USA.

出版信息

Photodiagnosis Photodyn Ther. 2012 Sep;9(3):232-42. doi: 10.1016/j.pdpdt.2012.01.003. Epub 2012 Feb 10.

Abstract

We report on some of the optical properties of Hemoporfin (hematoporphyrin monomethyl ether, HMME), a photodynamic therapy (PDT) photosensitizer that has been in clinical trials in China since the early 1990s. We characterized the photosensitizer on the basis of one- and two-photon absorption and fluorescence emission. The effects of photobleaching were probed to characterize its decay kinetics. Additionally, we determined time resolved fluorescence and thermal effects on fluorescence and absorption properties.

摘要

我们报告了血卟啉单甲醚(HMME)的一些光学性质,这是一种光动力疗法(PDT)光敏剂,自 20 世纪 90 年代初以来一直在中国进行临床试验。我们基于单光子和双光子吸收以及荧光发射对光敏剂进行了表征。探测光漂白效应以表征其衰减动力学。此外,我们还确定了对荧光和吸收特性的时间分辨荧光和热效应。

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