参数对Au@TiO-HMME核壳纳米结构光动力疗法的影响。
Influence of Parameters on Photodynamic Therapy of Au@TiO-HMME Core-Shell Nanostructures.
作者信息
Wang Ping, Zhang Luwei, Zhang Zhenxi, Wang Sijia, Yao Cuiping
机构信息
Key Laboratory of Biomedical Information Engineering of Ministry of Education, Institute of Biomedical Photonics and Sensing, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, China.
出版信息
Nanomaterials (Basel). 2022 Apr 15;12(8):1358. doi: 10.3390/nano12081358.
Photodynamic therapy (PDT) is a promising tumor therapy and has been proven to be an effective, safe and minimally invasive technique. Hematoporphyrin monomethyl ether (HMME) mediated PDT has been used in clinical treatment of port wine stain (PWS) due to its single component, high yield of singlet oxygen and short light-sensitive period. However, as an amphiphilic photosensitizer, HMME is easy to aggregate due to the presence of a hydrophobic group, which undesirably reduced its generation of singlet oxygen and bioavailability. In this study, we synthesized the stable conjugate of Au@TiO core-shell nanostructure with HMME, and the influence of different factors on PTD efficiency were studied. The results showed that the nanostructure had higher PTD efficiency for KB cells than that of HMME. The irradiation wavelength, gold nanoparticle shape and the shell thickness are all important factors for KB cell PDT.
光动力疗法（PDT）是一种很有前景的肿瘤治疗方法，已被证明是一种有效、安全且微创的技术。血卟啉单甲醚（HMME）介导的光动力疗法因其单一组分、单线态氧产率高和光敏感周期短，已被用于鲜红斑痣（PWS）的临床治疗。然而，作为一种两亲性光敏剂，HMME由于存在疏水基团而容易聚集，这不利地降低了其单线态氧的产生和生物利用度。在本研究中，我们合成了Au@TiO核壳纳米结构与HMME的稳定共轭物，并研究了不同因素对光动力疗法（PTD）效率的影响。结果表明，该纳米结构对KB细胞的光动力疗法（PTD）效率高于HMME。照射波长、金纳米颗粒形状和壳层厚度都是影响KB细胞光动力疗法（PDT）的重要因素。
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