胃饥饿素与进食障碍。
Ghrelin and eating disorders.
机构信息
Department of Medicine, New York Obesity Research and Nutrition Center, St. Luke's-Roosevelt Hospital, New York, NY, USA.
出版信息
Prog Neuropsychopharmacol Biol Psychiatry. 2013 Jan 10;40:70-82. doi: 10.1016/j.pnpbp.2012.08.011. Epub 2012 Aug 30.
Abstract
There is growing evidence supporting a multifactorial etiology that includes genetic, neurochemical, and physiological components for eating disorders above and beyond the more conventional theories based on psychological and sociocultural factors. Ghrelin is one of the key gut signals associated with appetite, and the only known circulating hormone that triggers a positive energy balance by stimulating food intake. This review summarizes recent findings and several conflicting reports on ghrelin in eating disorders. Understanding these findings and inconsistencies may help in developing new methods to prevent and treat patients with these disorders.
摘要
越来越多的证据支持饮食失调的多因素病因，包括遗传、神经化学和生理因素，超出了基于心理和社会文化因素的更传统理论。胃饥饿素是与食欲相关的关键肠道信号之一，也是唯一已知的循环激素，通过刺激食物摄入来引发正能平衡。本文综述了最近关于饮食失调中胃饥饿素的发现和一些相互矛盾的报告。了解这些发现和不一致性可能有助于开发预防和治疗这些疾病患者的新方法。
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