Department of Obstetrics and Gynecology, College of Medicine, Kosin University, Republic of Korea.
Food Chem Toxicol. 2012 Dec;50(12):4239-45. doi: 10.1016/j.fct.2012.08.047. Epub 2012 Aug 31.
Fruits of Schisandra have been traditionally used in East Asia for the treatment of dyspnea, cough, dysentery, insomnia, tonic-clonic seizures, and amnesia. Schisandrin B, a dibenzocyclooctadiene derivative isolated from Fructus Schisandrae, has been shown to produce antioxidant effect on rodent liver and heart. In the present study, we investigated the neuroprotective effects of Schisandrin B, a constituent drug of the fruit of Schisandra, against focal cerebral ischemia in rats. Schisandrin B (10, 30 mg/kg, i.p.) was twice administered 30 min before the onset of ischemia and 2h after reperfusion. Schisandrin B 10 and 30 mg/kg treated groups showed infarct volumes reduced by 25.7% and 53.4%, respectively, 2h after occlusion. Also, Schisandrin B treated animal treatment abrogated protein expression of TNF-α and IL-1β and degradation of MMP-2 and MMP-9 in ischemic hemispheres. These results suggest that Schisandrin B treatment provides a neuroprotective effect to rats after transient focal cerebral ischemia by inhibiting inflammation and by protecting against metalloproteinase degradation.
五味子的果实传统上被用于东亚治疗呼吸困难、咳嗽、痢疾、失眠、强直阵挛性发作和健忘症。从五味子果实中分离出的二苯并环辛二烯衍生物五味子素 B 已被证明对啮齿动物的肝脏和心脏具有抗氧化作用。在本研究中，我们研究了五味子素 B（五味子的一种成分药物）对大鼠局灶性脑缺血的神经保护作用。五味子素 B（10、30mg/kg，ip）在缺血开始前 30 分钟和再灌注后 2 小时两次给药。10mg/kg 和 30mg/kg 的五味子素 B 治疗组在闭塞后 2 小时分别显示梗死体积减少了 25.7%和 53.4%。此外，五味子素 B 治疗还消除了 TNF-α和 IL-1β 的蛋白表达，以及缺血半球中 MMP-2 和 MMP-9 的降解。这些结果表明，五味子素 B 治疗通过抑制炎症和保护金属蛋白酶降解，为短暂性局灶性脑缺血后的大鼠提供了神经保护作用。
