表皮的极性和分层。
Polarity and stratification of the epidermis.
机构信息
Department of Cell Biology, Duke University Medical Center, USA.
出版信息
Semin Cell Dev Biol. 2012 Oct;23(8):890-6. doi: 10.1016/j.semcdb.2012.08.008. Epub 2012 Aug 31.
Abstract
Polarity is a fundamental property of epithelial cells. In this review, we discuss our current knowledge of the polarity of a stratified epithelium, the epidermis, focusing on similarities and differences with simple epithelial models. We highlight how the differences in tissue architecture and physiology result in alterations in some aspects of cell polarity. In addition, we discuss one of the most prominent uses for cell polarity in the epidermis-orienting the mitotic spindle to drive the stratification and differentiation of this tissue during development.
摘要
极性是上皮细胞的一个基本特性。在这篇综述中，我们讨论了我们目前对分层上皮组织——表皮极性的认识，重点讨论了与简单上皮模型的相似之处和不同之处。我们强调了组织结构和生理学的差异如何导致细胞极性的某些方面发生改变。此外，我们还讨论了表皮中细胞极性的一个最突出的用途——为了在发育过程中驱动组织的分层和分化，使有丝分裂纺锤体定向。
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