整合素在细胞迁移中的作用。
Integrins in cell migration.
机构信息
Departments of Pediatrics and Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, Wsconsin 53706, USA.
出版信息
Cold Spring Harb Perspect Biol. 2011 Sep 1;3(9):a005074. doi: 10.1101/cshperspect.a005074.
Abstract
Integrin-based adhesion has served as a model for studying the central role of adhesion in migration. In this article, we outline modes of migration, both integrin-dependent and -independent in vitro and in vivo. We next discuss the roles of adhesion contacts as signaling centers and linkages between the ECM and actin that allows adhesions to serve as traction sites. This includes signaling complexes that regulate migration and the interplay among adhesion, signaling, and pliability of the substratum. Finally, we address mechanisms of adhesion assembly and disassembly and the role of adhesion in cellular polarity.
摘要
整合素介导的黏附作用为研究黏附在迁移中的核心作用提供了模型。本文概述了整合素依赖和非依赖的体外和体内迁移模式。接下来，我们讨论了黏附接触作为信号中心以及细胞外基质与肌动蛋白之间的连接的作用，这使得黏附可以作为牵引力位点。这包括调节迁移的信号复合物以及黏附、信号和基质柔韧性之间的相互作用。最后，我们讨论了黏附组装和拆卸的机制以及黏附在细胞极性中的作用。
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本文引用的文献
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Reducing background fluorescence reveals adhesions in 3D matrices.降低背景荧光可揭示三维基质中的粘连。
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Type I phosphatidylinositol phosphate kinase beta regulates focal adhesion disassembly by promoting beta1 integrin endocytosis.I 型磷酸肌醇磷酸激酶β通过促进β1 整合素内吞作用来调节焦点黏附解体。
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