皮肤发育和癌症中的极性。
Polarity in skin development and cancer.
机构信息
Departments of Dermatology and of Cell Biology, Duke University Medical Center, Durham, NC, United States.
Departments of Dermatology and of Cell Biology, Duke University Medical Center, Durham, NC, United States.
出版信息
Curr Top Dev Biol. 2023;154:317-336. doi: 10.1016/bs.ctdb.2023.02.003. Epub 2023 Mar 10.
The epidermis is a stratified squamous epithelium that forms the outermost layer of the skin. Its primary function is to act as a barrier, keeping pathogens and toxins out and moisture in. This physiological role has necessitated major differences in the organization and polarity of the tissue as compared to simple epithelia. We discuss four aspects of polarity in the epidermis - the distinctive polarities of basal progenitor cells as well as differentiated granular cells, the polarity of adhesions and the cytoskeleton across the tissue as keratinocytes differentiate, and the planar cell polarity of the tissue. These distinctive polarities are essential for the morphogenesis and the function of the epidermis and have also been implicated in regulating tumor formation.
表皮是一种复层扁平上皮，形成皮肤的最外层。它的主要功能是作为一道屏障，将病原体和毒素拒之门外，并保持水分。与简单上皮相比，这种生理作用使得组织在结构和极性上有很大的不同。我们讨论了表皮极性的四个方面——基底祖细胞和分化的颗粒细胞的独特极性、细胞间黏附及细胞骨架在角蛋白细胞分化过程中的极性，以及组织的平面细胞极性。这些独特的极性对于表皮的形态发生和功能至关重要，也与肿瘤形成的调节有关。
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