Department of Internal Medicine, Chungnam National University School of Medicine, Daejeon, Korea.
Dis Markers. 2012;33(4):193-9. doi: 10.3233/DMA-2012-0925.
The aim of this study was to investigate the role of the urinary chiro- and myo-inositol levels in predicting type 2 diabetes mellitus (T2DM).
A total of 212 normal controls and 101 type 2 diabetic patients were enrolled this study. The concentrations of urinary chiro- and myo-inositol were measured by high performance liquid chromatography/mass spectrometry.
The concentration of urinary chiro-inositol was significantly higher in the diabetic subjects (2.24 ± 5.18 ng/L) than those in the control group (0.38 ± 0.62 ng/L; p < 0.001). The urinary myo-inositol level of the diabetic subjects (36.95 ± 37.77 ng/L) was also significantly higher than that of the controls (8.17 ± 13.29 ng/L; p < 0.001). The urinary chiro-inositol multiplied by myo-inositol level of the diabetic subjects (148.10 ± 544.91) was significantly higher than in the controls (5.12 ± 24.15; p < 0.001). The area under the receiver operating characteristic curve for the urinary chiro-inositol multiplied by myo-inositol level to predict T2DM was 0.840 (confidence interval 0.789-0.891, p < 0.001). The cut-off value for the urinary chiro-inositol multiplied by myo-inositol level to predict T2DM was 2.20 (sensitivity 81.3%, specificity 70.3%).
The urinary chiro- and myo-inositol concentrations were increased in the type 2 diabetic patients and the urinary chiro- times the myo-inositol was considered to be a sufficient marker in predicting T2DM.
本研究旨在探讨尿手性肌醇和肌醇水平在预测 2 型糖尿病（T2DM）中的作用。
本研究共纳入 212 名正常对照者和 101 例 2 型糖尿病患者。采用高效液相色谱/质谱法测定尿手性肌醇和肌醇的浓度。
糖尿病患者尿手性肌醇浓度（2.24±5.18ng/L）明显高于对照组（0.38±0.62ng/L；p<0.001）。糖尿病患者尿肌醇水平（36.95±37.77ng/L）也明显高于对照组（8.17±13.29ng/L；p<0.001）。糖尿病患者尿手性肌醇乘以肌醇水平（148.10±544.91）明显高于对照组（5.12±24.15；p<0.001）。尿手性肌醇乘以肌醇水平预测 T2DM 的受试者工作特征曲线下面积为 0.840（置信区间 0.789-0.891，p<0.001）。预测 T2DM 时，尿手性肌醇乘以肌醇水平的截断值为 2.20（敏感性 81.3%，特异性 70.3%）。
2 型糖尿病患者尿手性肌醇和肌醇浓度升高，尿手性肌醇乘以肌醇被认为是预测 T2DM 的充分标志物。
