Suzuki S, Kawasaki H, Satoh Y, Ohtomo M, Hirai M, Hirai A, Hirai S, Onoda M, Matsumoto M, Hinokio Y
Third Department of Internal Medicine, Tohoku University School of Medicine, Sendai, Japan.
Diabetes Care. 1994 Dec;17(12):1465-8. doi: 10.2337/diacare.17.12.1465.
To determine the relationship between urinary chiro-inositol excretion and insulin sensitivity in Japanese type II diabetic patients.
Eighteen subjects were age-matched, nonobese, type II diabetic patients. Eight subjects had impaired glucose tolerance (IGT), and 10 had normal glucose tolerance (NGT). We quantified urinary chiro-inositol excretion using gas chromatography-mass spectrometry and the insulin sensitivity index (SI), and glucose effectiveness (SG) using Bergman's modified minimal model method.
The urinary excretion of chiro-inositol was much lower in the diabetic patients (32.3 +/- 16.0 mumol/day, means +/- SD) than in the NGT subjects (96.0 +/- 17.6; P < 0.0001) and IGT subjects (58.9 +/- 11.6; P < 0.0001). SI was much lower in the diabetic patients (3.81 +/- 1.49) than in the NGT subjects 6.30 +/- 1.59, P < 0.0005). SG was much lower in the diabetic patients (2.14 +/- 0.56) than in the NGT subjects (3.07 +/- 0.38, P < 0.0001). There was a significant correlation between urinary chiro-inositol excretion and SI (r = 0.766), as well as a significant correlation between urinary chiro-inositol excretion and SG (r = 0.747).
确定日本II型糖尿病患者尿手性肌醇排泄与胰岛素敏感性之间的关系。
18名受试者为年龄匹配的非肥胖II型糖尿病患者。其中8名受试者糖耐量受损（IGT），10名受试者糖耐量正常（NGT）。我们使用气相色谱-质谱法对尿手性肌醇排泄进行定量，并使用伯格曼改良的最小模型法对胰岛素敏感性指数（SI）和葡萄糖效能（SG）进行定量。
糖尿病患者尿手性肌醇排泄量（32.3±16.0μmol/天，均值±标准差）显著低于NGT受试者（96.0±17.6；P<0.0001）和IGT受试者（58.9±11.6；P<0.0001）。糖尿病患者的SI（3.81±1.49）显著低于NGT受试者（6.30±1.59，P<0.0005）。糖尿病患者的SG（2.14±0.56）显著低于NGT受试者（3.07±0.38，P<0.0001）。尿手性肌醇排泄与SI之间存在显著相关性（r=0.766），尿手性肌醇排泄与SG之间也存在显著相关性（r=0.747）。
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