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韩国糖尿病患者尿中肌醇/手性肌醇比值的测定。

Determination of urinary Myo-/chiro-inositol ratios from Korean diabetes patients.

作者信息

Jung Tae-Sik, Hahm Jong-Ryeal, Kim Jong-Jin, Jung Jung-Hwa, Kang Mi-Yeon, Moon Sung-Won, Lee Kang-Wan, Kim Ho-Cheol, Lee Jong-Deog, Kim Ji-Hye, Kim Deok-Ryong, Chung Soon-Il

机构信息

Department of Internal Medicine, Gyeongsang National University, Jinju 660- 702, Korea.

出版信息

Yonsei Med J. 2005 Aug 31;46(4):532-8. doi: 10.3349/ymj.2005.46.4.532.

DOI:10.3349/ymj.2005.46.4.532
PMID:16127779
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2815839/
Abstract

Of two major forms (myo- and chiro-inositol) of inositols, only chiro-inositol enhances the activity of proteins involved in intracellular glucose metabolism. This study aims to determine the urinary myo-/chiro-inositol ratio in type 1 and type 2 diabetes patients and compare its ratio with the normal control group. The 24-hour urinary myo- and chiro-inositols in 71 Korean diabetes patients and 39 control subjects have been quantified using high-performance liquid chromatography, and their ratios have been evaluated as indices of insulin resistance. The level of 24-hour urinary myo-inositol was significantly higher in both type 1 and type 2 diabetes than with the control group, whereas the urinary chiro-inositol in type 1 or type 2 diabetes was lower than that in normal subjects. The myo-/chiro-inositol ratio in diabetes patients was higher than that in the control group. Twenty four-hour urinary myo-/ chiro-inositol ratios were significantly elevated in type 1 and type 2 diabetes patients compared to the control group, suggesting that a high ratio of urinary myo-/chiro- inositol in type 2 diabetes patients might be used for an index of insulin resistance.

摘要

在肌醇的两种主要形式（肌醇和手性肌醇）中，只有手性肌醇能增强参与细胞内葡萄糖代谢的蛋白质的活性。本研究旨在测定1型和2型糖尿病患者尿中肌醇/手性肌醇的比值，并将其与正常对照组进行比较。采用高效液相色谱法对71例韩国糖尿病患者和39例对照者的24小时尿肌醇和手性肌醇进行了定量，并将其比值作为胰岛素抵抗的指标进行了评估。1型和2型糖尿病患者24小时尿肌醇水平均显著高于对照组，而1型或2型糖尿病患者尿手性肌醇水平低于正常受试者。糖尿病患者的肌醇/手性肌醇比值高于对照组。与对照组相比，1型和2型糖尿病患者24小时尿肌醇/手性肌醇比值显著升高，提示2型糖尿病患者尿肌醇/手性肌醇比值升高可能作为胰岛素抵抗的指标。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0fce/2815839/7e62ab1b0695/ymj-46-532-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0fce/2815839/7e62ab1b0695/ymj-46-532-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0fce/2815839/7e62ab1b0695/ymj-46-532-g001.jpg

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J Clin Endocrinol Metab. 2001 Apr;86(4):1626-32. doi: 10.1210/jcem.86.4.7375.
2
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JAMA. 2000 Dec 20;284(23):3043-5.
3
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4
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