Division of Anti-Ageing and Longevity Sciences, Department of Medical Technology, Toin University of Yokohama, Japan.
Exp Gerontol. 2012 Dec;47(12):936-9. doi: 10.1016/j.exger.2012.08.010. Epub 2012 Aug 31.
Minor inflammation-driven aging (inflammaging) has been proposed to explain human aging mechanism. To study the inflammatory condition associated with normal human aging, highly sensitive CRP (hsCRP) was examined in the sera collected from 217 healthy Japanese individuals aged between 1 and 100years and 41 mutation-proven Japanese Werner syndrome (WS) patients. The serum hsCRP was assayed by ELISA. The serum hsCRP level increased significantly (p<0.001) with normal aging from both sexes. The serum hsCRP was significantly elevated in WS (mean±SE: 11.0±1.6μg/ml) compared with age-matched normal population (1.3±0.3μg/ml, p<0.001) and normal elderly population ages between 71 and 100years (4.2±0.7μg/ml, p<0.001). Both normal aging and WS were associated with minor inflammation that can be evaluated by serum hsCRP. WS may be a good candidate to study inflammaging.
已经有人提出，轻微的炎症驱动的衰老（inflammaging）可以解释人类衰老的机制。为了研究与正常人类衰老相关的炎症状态，我们检测了来自 217 名年龄在 1 至 100 岁之间的健康日本个体和 41 名经突变证实的日本 Werner 综合征（WS）患者血清中的高敏 C 反应蛋白（hsCRP）。采用 ELISA 法检测血清 hsCRP。结果显示，血清 hsCRP 水平随着正常衰老而显著升高（p<0.001），无论男女。WS 患者的血清 hsCRP 水平明显高于年龄匹配的正常人群（1.3±0.3μg/ml，p<0.001）和 71 至 100 岁的正常老年人群（4.2±0.7μg/ml，p<0.001）。正常衰老和 WS 均与可以通过血清 hsCRP 评估的轻微炎症有关。WS 可能是研究 inflammaging 的一个很好的候选者。
