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Soluble CD4 enhances the efficacy of immunotoxins directed against gp41 of the human immunodeficiency virus.可溶性CD4增强了针对人类免疫缺陷病毒gp41的免疫毒素的疗效。
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8
Increased levels of interferon-gamma (IFN-gamma), IL-4 and transforming growth factor-beta (TGF-beta) mRNA expressing blood mononuclear cells in human HIV infection.人类HIV感染中表达干扰素-γ（IFN-γ）、白细胞介素-4（IL-4）和转化生长因子-β（TGF-β）mRNA的血液单核细胞水平升高。
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Two immunodominant domains of gp41 bind antibodies which enhance human immunodeficiency virus type 1 infection in vitro.gp41的两个免疫显性结构域可结合抗体，这些抗体在体外可增强1型人类免疫缺陷病毒的感染。
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Hyperimmune antisera against synthetic peptides representing the glycoprotein of human immunodeficiency virus type 2 can mediate neutralization and antibody-dependent cytotoxic activity.针对代表2型人类免疫缺陷病毒糖蛋白的合成肽的超免疫抗血清可介导中和作用及抗体依赖性细胞毒活性。
Proc Natl Acad Sci U S A. 1991 Jul 15;88(14):6082-6. doi: 10.1073/pnas.88.14.6082.

本文引用的文献

1
IgG2a monoclonal antibodies inhibit human tumor growth through interaction with effector cells.IgG2a单克隆抗体通过与效应细胞相互作用抑制人类肿瘤生长。
Proc Natl Acad Sci U S A. 1982 Aug;79(15):4761-5. doi: 10.1073/pnas.79.15.4761.
2
Cell-mediated lysis of tumor targets directed by murine monoclonal antibodies of IgM and all IgG isotypes.由IgM及所有IgG同种型的鼠单克隆抗体介导的肿瘤靶细胞的细胞介导裂解。
J Immunol. 1983 Aug;131(2):1028-31.
3
Importance of immunoglobulin isotype in human antibody-dependent, cell-mediated cytotoxicity directed by murine monoclonal antibodies.免疫球蛋白同种型在小鼠单克隆抗体介导的人抗体依赖性细胞介导的细胞毒性中的重要性。
J Exp Med. 1985 Jan 1;161(1):1-17. doi: 10.1084/jem.161.1.1.
4
Antibody-dependent cellular cytotoxicity-inducing antibodies against human immunodeficiency virus. Presence at different clinical stages.针对人类免疫缺陷病毒的抗体依赖性细胞毒性诱导抗体。在不同临床阶段的存在情况。
J Immunol. 1987 Oct 1;139(7):2263-7.
5
IgG subclass response to HIV in relation to antibody-dependent cellular cytotoxicity at different clinical stages.不同临床阶段IgG亚类对HIV的应答与抗体依赖性细胞毒性的关系
Clin Exp Immunol. 1988 Sep;73(3):343-7.
6
Neutralization of the AIDS retrovirus by antibodies to a recombinant envelope glycoprotein.针对重组包膜糖蛋白的抗体对艾滋病逆转录病毒的中和作用。
Science. 1986 Jul 11;233(4760):209-12. doi: 10.1126/science.3014647.
7
HTLV-III-neutralizing antibodies in patients with AIDS and AIDS-related complex.艾滋病及艾滋病相关综合征患者体内的人嗜T淋巴细胞病毒III型中和抗体
Nature. 1985;316(6023):72-4. doi: 10.1038/316072a0.
8
Neutralization of human T-lymphotropic virus type III by sera of AIDS and AIDS-risk patients.艾滋病患者及有艾滋病风险患者的血清对人类Ⅲ型嗜T淋巴细胞病毒的中和作用。
Nature. 1985;316(6023):69-72. doi: 10.1038/316069a0.
9
Human large granular lymphocytes express high affinity receptors for murine monoclonal antibodies of the IgG3 subclass.人类大颗粒淋巴细胞表达针对IgG3亚类鼠单克隆抗体的高亲和力受体。
J Immunol. 1987 May 1;138(9):2979-81.
10
Anti-GP 120 antibodies from HIV seropositive individuals mediate broadly reactive anti-HIV ADCC.来自HIV血清阳性个体的抗GP 120抗体介导广泛反应性抗HIV ADCC。
AIDS Res Hum Retroviruses. 1987;3(4):409-22. doi: 10.1089/aid.1987.3.409.

一种针对1型人类免疫缺陷病毒的单克隆抗体，其介导细胞毒性和中和作用。

A monoclonal antibody to human immunodeficiency virus type 1 which mediates cellular cytotoxicity and neutralization.

作者信息

Broliden P A, Ljunggren K, Hinkula J, Norrby E, Akerblom L, Wahren B

机构信息

Department of Virology, Karolinska Institute, Stockholm, Sweden.

出版信息

J Virol. 1990 Feb;64(2):936-40. doi: 10.1128/JVI.64.2.936-940.1990.

DOI:10.1128/JVI.64.2.936-940.1990
PMID:2296090
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC249194/
Abstract

Monoclonal antibodies (MAbs) were raised against human immunodeficiency virus type 1 gp120. One MAb, P4/D10, was found to mediate highly efficient antibody-dependent cellular cytotoxicity and virus neutralization. The reactivity was located to a major neutralizing region (amino acids 304 to 323) on gp120. Five other MAbs with a similar epitopic reactivity did not show any antibody-dependent cellulan cytotoxicity activity but had a virus-neutralizing capacity.

摘要

制备了针对人免疫缺陷病毒1型gp120的单克隆抗体（MAb）。发现一种单克隆抗体P4/D10可介导高效的抗体依赖性细胞毒性和病毒中和作用。其反应活性定位于gp120上的一个主要中和区域（氨基酸304至323）。其他五种具有相似表位反应性的单克隆抗体未显示任何抗体依赖性细胞毒性活性，但具有病毒中和能力。