一种针对1型人类免疫缺陷病毒的单克隆抗体，其介导细胞毒性和中和作用。
A monoclonal antibody to human immunodeficiency virus type 1 which mediates cellular cytotoxicity and neutralization.
作者信息
Broliden P A, Ljunggren K, Hinkula J, Norrby E, Akerblom L, Wahren B
机构信息
Department of Virology, Karolinska Institute, Stockholm, Sweden.
出版信息
J Virol. 1990 Feb;64(2):936-40. doi: 10.1128/JVI.64.2.936-940.1990.
Abstract
Monoclonal antibodies (MAbs) were raised against human immunodeficiency virus type 1 gp120. One MAb, P4/D10, was found to mediate highly efficient antibody-dependent cellular cytotoxicity and virus neutralization. The reactivity was located to a major neutralizing region (amino acids 304 to 323) on gp120. Five other MAbs with a similar epitopic reactivity did not show any antibody-dependent cellulan cytotoxicity activity but had a virus-neutralizing capacity.
摘要
制备了针对人免疫缺陷病毒1型gp120的单克隆抗体（MAb）。发现一种单克隆抗体P4/D10可介导高效的抗体依赖性细胞毒性和病毒中和作用。其反应活性定位于gp120上的一个主要中和区域（氨基酸304至323）。其他五种具有相似表位反应性的单克隆抗体未显示任何抗体依赖性细胞毒性活性，但具有病毒中和能力。
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