Cancer Genomics Branch, Research Institute, National Cancer Center, Goyang, Gyeonggi-do 410-769, Republic of Korea.
Int J Oncol. 2012 Nov;41(5):1675-82. doi: 10.3892/ijo.2012.1621. Epub 2012 Sep 6.
To elucidate the molecular basis of early gastric cancer (EGC), the genome-wide expression pattern of cancer and normal tissues from 27 patients were analyzed by a microarray-based method. Using an integrative systematic bioinformatics approach, we classified the differentially expressed genes in EGC. Interestingly, the more highly expressed genes in EGC exhibited the most significant correlation with cell migration and metastasis. This implies that, even at the early stage of gastric cancer, the molecular properties usually observed in late-stage cancer are already present. Furthermore, we have found a novel association between the expression pattern and molecular pathways of EGC and estrogen receptor α (ERα)-negative breast cancer through cross-experimental analysis. These results provide new insights into the biological properties of EGC, as well as yielding useful basic data for the study of molecular mechanisms of EGC carcinogenesis.
为了阐明早期胃癌（EGC）的分子基础，我们通过基于微阵列的方法分析了 27 例患者的癌症和正常组织的全基因组表达模式。使用综合系统生物信息学方法，我们对 EGC 中的差异表达基因进行了分类。有趣的是，EGC 中表达水平较高的基因与细胞迁移和转移的相关性最为显著。这意味着，即使在胃癌的早期阶段，通常在晚期癌症中观察到的分子特征已经存在。此外，我们通过交叉实验分析发现了 EGC 与雌激素受体α（ERα）阴性乳腺癌的表达模式和分子途径之间的新关联。这些结果为 EGC 的生物学特性提供了新的见解，并为研究 EGC 癌变的分子机制提供了有用的基础数据。
