State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, PR China.
Angew Chem Int Ed Engl. 2013 Jan 2;52(1):441-5. doi: 10.1002/anie.201204796. Epub 2012 Sep 7.
Getting axed: synthesis of the title amines, bearing functionality (R(1) and R(2)), involves the enantioselective palladium-catalyzed decarboxylation of allenyl N-tosylcarbamates. The reaction proceeds smoothly using both the chiral ligands (S)- and (R)-DTBM-Segphos (1) to afford the allenyl amines in good yields and with high enantioseletivities.
标题胺的合成，具有功能（R(1)和 R(2)），涉及烯丙基 N-对甲苯磺酰基氨基甲酸酯的对映选择性钯催化脱羧。使用手性配体 (S)-和 (R)-DTBM-Segphos（1），该反应顺利进行，以高收率和高对映选择性得到烯丙基胺。
