Department of Pathology, The University of Texas MD Anderson Cancer Centre, 1515 Holcombe Blvd., Houston, TX 77030, USA.
Histopathology. 2013 Jan;62(2):267-74. doi: 10.1111/j.1365-2559.2012.04344.x. Epub 2012 Sep 11.
In addition to oestrogen and progesterone receptors, gross cystic disease fluid protein-15 (GCDFP-15) and mammaglobin A (MAM) are the most common markers used to identify breast origin by immunohistochemistry. GCDFP-15 expression has been reported in approximately 60% of breast carcinomas and MAM expression in approximately 80%. Data on their expression in triple-negative breast cancer (TNBC) are very limited. The aim of this study was to examine the expression of these markers in TNBC to determine their utility in pathological diagnosis.
We studied the immunohistochemical (IHC) expression of GCDFP-15 and MAM in 63 primary and 118 metastatic TNBCs. GCDFP-15 staining was present in 14% of primary and 21% of metastatic TNBCs. MAM staining was present in 25% of primary and 41% of metastatic TNBCs. The frequency of expression of GCDFP-15 and/or MAM was 30% in primary and 43% in metastatic TNBCs, and many positive tumours had only focal staining.
Staining for GCDFP-15 and/or MAM in triple-negative carcinomas helps to confirm breast origin, but most tumours in this subgroup of breast carcinomas lack expression of either marker.
除了雌激素受体和孕激素受体， gross cystic disease fluid protein-15 (GCDFP-15) 和 mammaglobin A (MAM) 也是免疫组织化学中最常用于识别乳腺来源的常见标志物。GCDFP-15 在大约 60%的乳腺癌中表达，MAM 在大约 80%的乳腺癌中表达。关于它们在三阴性乳腺癌 (TNBC) 中的表达的数据非常有限。本研究旨在检测这些标志物在 TNBC 中的表达情况，以确定它们在病理诊断中的应用价值。
我们研究了 63 例原发性和 118 例转移性 TNBC 中 GCDFP-15 和 MAM 的免疫组化 (IHC) 表达。GCDFP-15 染色在 14%的原发性和 21%的转移性 TNBC 中存在。MAM 染色在 25%的原发性和 41%的转移性 TNBC 中存在。GCDFP-15 和/或 MAM 的表达频率在原发性 TNBC 中为 30%，在转移性 TNBC 中为 43%，许多阳性肿瘤只有局灶性染色。
在三阴性癌中染色 GCDFP-15 和/或 MAM 有助于确认乳腺来源，但该组乳腺癌中的大多数肿瘤缺乏任一标志物的表达。
