Shirian Faeze, Kheradmand Parvin, Ranjbari Nastaran, Shahbazian Hodjatollah, Latifi Seyed Mahmoud
Department of Pathology, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Cancer Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Iran J Pathol. 2023;18(1):75-81. doi: 10.30699/ijp.2023.558196.2945. Epub 2023 Mar 22.
BACKGROUND & OBJECTIVE: During the last decade, biological markers of breast cancer have been considered to predict the degree of histology, behavior, and extent of tumor invasion and the possibility of lymph node involvement. The aim of this study was to evaluate the expression of GCDFP-15 in different grades of invasive ductal carcinoma, as the most common type of breast cancer.
In this retrospective study, paraffin blocks of tumors of 60 breast cancer patients registered in the histopathology laboratory of Imam Khomeini Hospital in Ahvaz between 2019 and 2020 were reviewed. Information on grade, invasion, stage and lymph node involvement was extracted from the pathology reports and immunohistochemical staining for GCDFP-15 was performed. Data were analyzed by SPSS 22.
GCDFP-15 marker expression was observed in 20 out of 60 breast cancer patients (33.3%). GCDFP-15 staining intensity was weak in 7 cases (35%), moderate in 8 cases (40%), and strong in 5 cases (25%). The patient's age and sex showed no significant relationship with the expression of GCDFP-15 and intensity of staining. Expression of the GCDFP-15 marker was correlated significantly with tumor grade, stage, and vascular invasion (<0.05)) and its expression was higher in tumors with a lower grade, less depth of invasion, and no vascular invasion but unrelated to perineural invasion, lymph node involvement, and tumor size. The intensity of staining for GCDFP-15 showed significant relationship with the tumor grade (<0.0001) but unrelated to the other factors.
GCDFP-15 marker may be significantly associated with tumor grade, depth of invasion, and vascular invasion, thus can be used as a prognostic marker.
在过去十年中，乳腺癌的生物标志物被认为可预测组织学程度、行为、肿瘤侵袭范围以及淋巴结受累的可能性。本研究的目的是评估GCDFP - 15在不同分级的浸润性导管癌（最常见的乳腺癌类型）中的表达情况。
在这项回顾性研究中，对2019年至2020年在阿瓦士伊玛目霍梅尼医院组织病理学实验室登记的60例乳腺癌患者的肿瘤石蜡块进行了复查。从病理报告中提取有关分级、侵袭、分期和淋巴结受累的信息，并进行GCDFP - 15的免疫组织化学染色。数据采用SPSS 22进行分析。
60例乳腺癌患者中有20例（33.3%）观察到GCDFP - 15标志物表达。GCDFP - 15染色强度为弱阳性的有7例（35%），中度阳性的有8例（40%），强阳性的有5例（25%）。患者的年龄和性别与GCDFP - 15的表达及染色强度无显著关系。GCDFP - 15标志物的表达与肿瘤分级、分期和血管侵犯显著相关（<0.05），其在分级较低、侵袭深度较小且无血管侵犯的肿瘤中表达较高，但与神经周围侵犯、淋巴结受累和肿瘤大小无关。GCDFP - 15的染色强度与肿瘤分级显著相关（<0.0001），但与其他因素无关。
GCDFP - 15标志物可能与肿瘤分级、侵袭深度和血管侵犯显著相关，因此可作为一种预后标志物。
