共轭聚电解质的荧光生物成像。

Fluorescence bioimaging with conjugated polyelectrolytes.

机构信息

Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore 117576.

出版信息

Nanoscale. 2012 Oct 21;4(20):6150-65. doi: 10.1039/c2nr31392h.

DOI:10.1039/c2nr31392h

PMID:22964921

Abstract

This review summarizes the recent developments in fluorescent conjugated polyelectrolytes (CPEs) in bioimaging. The CPEs discussed include linear-, hyperbranched-, and polyhedral oligomeric silsesquioxanes (POSS)-based derivatives. Originating from their special optical properties, good photostability, low cytotoxicity, ease of bioconjugation and tuneable size, CPEs have shown wide applications in in vitro and in vivo protein and cell imaging, drug tracking and gene delivery. Moreover, some CPEs also possess antibacterial and anticancer characteristics as well as apoptosis imaging functions. Finally, this review discusses the future outlook of CPEs in bioimaging applications.

摘要

本文综述了近年来荧光共轭聚合物在生物成像中的最新进展。讨论的 CPEs 包括线性、超支化和多面体低聚倍半硅氧烷（POSS）基衍生物。由于其特殊的光学性质、良好的光稳定性、低细胞毒性、易于生物偶联和可调尺寸，CPEs 在体外和体内蛋白质和细胞成像、药物跟踪和基因传递方面有广泛的应用。此外，一些 CPEs 还具有抗菌和抗癌特性以及细胞凋亡成像功能。最后，本文讨论了 CPEs 在生物成像应用中的未来展望。