Programa de Pós-Graduação em Patologia, Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, RS, Brasil.
J Bras Pneumol. 2012 Jul-Aug;38(4):487-93. doi: 10.1590/s1806-37132012000400011.
The objective of this study was to identify the clinical and pathological factors that can influence the prognosis of breast cancer patients with clinical symptoms of malignant pleural effusion.
This was a clinical cohort study, in which we analyzed the medical charts of patients diagnosed with malignant pleural effusion between 2006 and 2010. By examining the charts, we identified the female patients with a history of breast cancer. For those patients, we collected pathology data related to the primary tumor and cytopathology data related to the pleural metastasis.
We evaluated 145 patients, 87 (60%) of whom had tested positive for malignant cells in the pleural fluid. Ductal histology was observed in 119 (82%). The triple-negative breast cancer phenotype was seen in 25 cases (17%). Those patients had the worst prognosis (with a sharp decline in the survival curve), and 20 of the 25 (80%) died during the follow-up period (through June of 2011). The mean survival after the identification of malignant pleural effusion was 6 months.
In patients with triple-negative breast cancer who test positive for malignant cells in the pleural fluid, the prognosis is poor and survival is reduced.
本研究旨在确定影响有恶性胸腔积液临床症状的乳腺癌患者预后的临床和病理因素。
这是一项临床队列研究，我们分析了 2006 年至 2010 年间诊断为恶性胸腔积液的患者的病历。通过检查病历，我们确定了有乳腺癌病史的女性患者。对于这些患者，我们收集了与原发性肿瘤相关的病理数据和与胸腔转移相关的细胞学数据。
我们评估了 145 名患者，其中 87 名（60%）胸腔积液中的恶性细胞检测呈阳性。119 名（82%）为导管组织学。25 例（17%）为三阴性乳腺癌表型。这些患者的预后最差（生存曲线急剧下降），25 例中有 20 例（80%）在随访期间（截至 2011 年 6 月）死亡。从确诊恶性胸腔积液后，平均生存时间为 6 个月。
在胸腔积液中恶性细胞检测呈阳性的三阴性乳腺癌患者中，预后较差，生存时间缩短。
