Schmidt-Kassow Maren, Schädle Sarah, Otterbein Sascha, Thiel Christian, Doehring Alexandra, Lötsch Jörn, Kaiser Jochen
aInstitute of Medical Psychology, Department of Sports Medicine, Goethe University, Frankfurt am Main, Germany.
Neuroreport. 2012 Oct 24;23(15):889-93. doi: 10.1097/WNR.0b013e32835946ca.
Physical activity has been shown to enhance circulating brain-derived neurotrophic factor (BDNF) in animals and humans. However, the exact time course and sex-specific modulation of peripheral BDNF in response to exercise are still poorly understood. We examined the kinetics of BDNF serum concentrations in response to perceived high-intensity and low-intensity exercise, and during a subsequent recovery period by taking several blood samples during each phase. Furthermore, we compared the BDNF concentration between young men and women taking oral contraceptives. We found transient BDNF elevations during physical activity only for the high-intensity condition. Here, BDNF reached its maximum serum concentration after 20 min of exercise, and returned to baseline after approximately 10 min of recovery. Although there were no sex differences during baseline or recovery, the increase in the BDNF concentration during the exercise phase was more pronounced in men than in women.
体力活动已被证明可提高动物和人类体内循环的脑源性神经营养因子（BDNF）水平。然而，运动对外周BDNF的确切时间进程和性别特异性调节仍知之甚少。我们通过在每个阶段采集多个血样，研究了感知到的高强度和低强度运动以及随后恢复期外周BDNF的动力学变化。此外，我们比较了服用口服避孕药的年轻男性和女性之间的BDNF浓度。我们发现，仅在高强度运动时，体力活动期间BDNF会出现短暂升高。在此情况下，运动20分钟后BDNF达到血清最高浓度，恢复约10分钟后回到基线水平。虽然在基线期或恢复期没有性别差异，但运动阶段男性BDNF浓度的升高比女性更明显。
