Gan Jianyu, He Jiya, Zhou Kaixiang, Shang Zhangyuting, Dong Gengxin, Bao Dapeng, Zhou Junhong
Sports Coaching College, Beijing Sport University, Beijing, China.
School of Strength and Conditioning Training, Beijing Sport University, Beijing, China.
J Exerc Sci Fit. 2025 Jan;23(1):32-41. doi: 10.1016/j.jesf.2024.12.004. Epub 2024 Dec 17.
Brain-derived neurotrophic factor (BDNF) may help middle-aged and older adults resist age-related neurodegenerative conditions and psychiatric disorders. Recent studies suggested that Traditional Chinese exercises (TCEs) may be a promising strategy to improve the BDNF levels of these populations, while the effectiveness has yet to be definitively confirmed due to the variances in the study designs and observations. Therefore, this systematic review and meta-analysis aimed to examine the effects of TCEs intervention on BDNF in middle-aged and older adults.
The search was conducted in November 2024 in seven Chinese and English databases. Two reviewers independently reviewed the search results, extracted the data, and assessed the risk of bias and certainty of evidence. Meta-analyses and meta-regressions were performed to determine the overall effect size and the impact of potential moderators.
Ten publications consisting of 543 participants were included. The overall effect size of TCEs on BDNF was large and significant [Hedges'g = 0.82, 95 % CI (0.55, 1.09), p < 0.01]. Subgroup analysis revealed that the effect size was non-significant for participants with mild cognitive impairment (MCI) (p = 0.08), while significant for participants with normal cognitive function (p < 0.01). In the meta-regression, moderators such as the mean age, sex, and baseline BDNF levels of participants, as well as total TCEs time were not associated with outcome variables. The certainty of the evidence was assessed as moderate.
This systematic review and meta-analysis indicates that TCEs intervention could increase the levels of BDNF in middle-aged and older adults with normal cognitive function.
www.crd.york.ac.uk/PROSPERO/, identifier: CRD42023484121.
脑源性神经营养因子（BDNF）可能有助于中老年人抵抗与年龄相关的神经退行性疾病和精神障碍。最近的研究表明，传统中国运动（TCEs）可能是提高这些人群BDNF水平的一种有前景的策略，然而由于研究设计和观察结果的差异，其有效性尚未得到明确证实。因此，本系统评价和荟萃分析旨在研究TCEs干预对中老年人BDNF的影响。
2024年11月在7个中英文数据库中进行检索。两名 reviewers 独立审查检索结果，提取数据，并评估偏倚风险和证据的确定性。进行荟萃分析和荟萃回归以确定总体效应大小和潜在调节因素的影响。
纳入了10篇包含543名参与者的出版物。TCEs 对 BDNF 的总体效应大小很大且具有统计学意义[Hedges'g = 0.82，95%CI（0.55，1.09），p < 0.01]。亚组分析显示，轻度认知障碍（MCI）参与者的效应大小无统计学意义（p = 0.08），而认知功能正常的参与者效应显著（p < 0.01）。在荟萃回归中，参与者的平均年龄、性别、基线 BDNF 水平以及 TCEs 总时长等调节因素与结局变量无关。证据的确定性被评估为中等。
本系统评价和荟萃分析表明，TCEs 干预可提高认知功能正常的中老年人的 BDNF 水平。
