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CFTR: an ion channel with a transporter-type energy-coupling mechanism.

作者信息

Tsai Ming-Feng

机构信息

Department of Biochemistry, Howard Hughes Medical Institute, Brandeis University, Waltham, MA 02454, USA.

出版信息

J Gen Physiol. 2012 Oct;140(4):343-5. doi: 10.1085/jgp.201210882. Epub 2012 Sep 10.

DOI:10.1085/jgp.201210882
PMID:22966013
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3457686/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a006/3457686/3e34bf31674b/JGP_201210882_Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a006/3457686/3e34bf31674b/JGP_201210882_Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a006/3457686/3e34bf31674b/JGP_201210882_Fig1.jpg

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本文引用的文献

1
Nonintegral stoichiometry in CFTR gating revealed by a pore-lining mutation.由一个孔衬突变揭示的 CFTR 门控中非整比化学计量。
J Gen Physiol. 2012 Oct;140(4):347-59. doi: 10.1085/jgp.201210834. Epub 2012 Sep 10.
2
Strict coupling between CFTR's catalytic cycle and gating of its Cl- ion pore revealed by distributions of open channel burst durations.严格偶联 CFTR 的催化循环及其 Cl- 离子通道门控揭示的开放通道爆发持续时间分布。
Proc Natl Acad Sci U S A. 2010 Jan 19;107(3):1241-6. doi: 10.1073/pnas.0911061107. Epub 2009 Dec 4.
3
State-dependent modulation of CFTR gating by pyrophosphate.
焦磷酸对 CFTR 门控的状态依赖性调节。
J Gen Physiol. 2009 Apr;133(4):405-19. doi: 10.1085/jgp.200810186.
4
ABC transporters: the power to change.ABC转运蛋白：改变的力量。
Nat Rev Mol Cell Biol. 2009 Mar;10(3):218-27. doi: 10.1038/nrm2646.
5
Structural insights into ABC transporter mechanism.ABC转运蛋白机制的结构解析
Curr Opin Struct Biol. 2008 Dec;18(6):726-33. doi: 10.1016/j.sbi.2008.09.007. Epub 2008 Nov 5.
6
CFTR (ABCC7) is a hydrolyzable-ligand-gated channel.囊性纤维化跨膜传导调节因子（ABCC7）是一种可水解配体门控通道。
Pflugers Arch. 2007 Feb;453(5):693-702. doi: 10.1007/s00424-006-0140-z. Epub 2006 Sep 26.
7
On the mechanism of MgATP-dependent gating of CFTR Cl- channels.关于CFTR氯离子通道MgATP依赖性门控的机制
J Gen Physiol. 2003 Jan;121(1):17-36. doi: 10.1085/jgp.20028673.
8
Mutation of Walker-A lysine 464 in cystic fibrosis transmembrane conductance regulator reveals functional interaction between its nucleotide-binding domains.囊性纤维化跨膜传导调节因子中沃克-A赖氨酸464的突变揭示了其核苷酸结合结构域之间的功能相互作用。
J Physiol. 2002 Mar 1;539(Pt 2):333-46. doi: 10.1113/jphysiol.2001.013162.
9
A conditional probability analysis of cystic fibrosis transmembrane conductance regulator gating indicates that ATP has multiple effects during the gating cycle.囊性纤维化跨膜传导调节因子门控的条件概率分析表明，三磷酸腺苷（ATP）在门控周期中具有多种作用。
Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3594-9. doi: 10.1073/pnas.051633298. Epub 2001 Mar 6.
10
The non-hydrolytic pathway of cystic fibrosis transmembrane conductance regulator ion channel gating.囊性纤维化跨膜传导调节因子离子通道门控的非水解途径
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