College of Animal Science, South China Agricultural University, Guangzhou, China.
J Virol. 2012 Oct;86(19):10907-8. doi: 10.1128/JVI.01894-12.
Subgroup J avian leukosis virus (ALV-J) was first isolated from meat-type chickens that developed myeloid leukosis (ML). In recent years, field cases of hemangioma (HE) or HE and ML, rather than ML alone, have been reported in commercial layer flocks exposed to ALV-J with a high incidence in China. Here we report the complete genomic sequence of an ALV-J isolate that caused both HE and ML in egg-type and meat-type chickens in China. These findings will provide additional insights into the molecular characteristics in genomes, host range, and pathogenicity of ALV-J.
亚群 J 禽白血病病毒(ALV-J)最初是从发生骨髓性白血病(ML)的肉用型鸡中分离出来的。近年来,在中国,与 ALV-J 接触的商业蛋鸡群中,除了 ML 之外,还报告了血管瘤(HE)或 HE 和 ML 的病例,且发病率较高。本文报告了一株 ALV-J 分离株在中国蛋鸡和肉鸡中引起 HE 和 ML 的完整基因组序列。这些发现将为 ALV-J 的基因组、宿主范围和致病性的分子特征提供更多的了解。