细胞色素P-450催化的异源物质代谢中活性氧的形式。
Activated forms of oxygen in the metabolism of xenobiotics catalyzed by cytochrome P-450.
作者信息
Lyakhovich V V, Tsyrlov I B, Mishin V M, Weiner L M, Rumyantseva G, Eremenko S I, Budker V G
出版信息
Acta Biol Med Ger. 1979;38(2-3):201-6.
PMID:229676
Abstract
The Cu(Lys)2 complex is shown to be an effective inhibitor of the oxidation of 3,4-benzpyrene and aniline in microsomes. Apparently, this is due to the dismutation of superoxide radicals involved in the metabolism of these compounds. Possible interactions between Cu(Lys)2 and model membranes have been studied using spin probes. A model has been suggested according to which Cu(Lys)2 "builds" in the membrane hydrocarbon regions.
摘要
已表明Cu（Lys）2络合物是微粒体中3,4 - 苯并芘和苯胺氧化的有效抑制剂。显然，这是由于参与这些化合物代谢的超氧自由基的歧化作用。已使用自旋探针研究了Cu（Lys）2与模型膜之间可能的相互作用。有人提出了一个模型，根据该模型，Cu（Lys）2“嵌入”膜的烃区域。
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