Nakamura-Ishizu Ayako, Suda Toshio
Department of Cell Differentiation, The Sakaguchi Laboratory, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.
Biochim Biophys Acta. 2013 Feb;1830(2):2404-9. doi: 10.1016/j.bbagen.2012.08.023. Epub 2012 Sep 4.
Hematopoietic stem cell (HSC) niche of the BM provides a specialized microenvironment for the regulation of HSCs. The strict control of HSCs by the niche coordinates the balance between the proliferation and the differentiation of HSCs for the homeostasis of the blood system in steady states and during stress hematopoiesis. The osteoblastic and vascular niches are the classically identified constituents of the BM niche.
Recent research broadens our understanding of the BM niche as an assembly of multiple niche cells within the BM. We provide an overview of the HSC niche aiming to delineate the defined and possible niche cell interactions which collectively modulate the HSC integrity.
Multiple cells in the BM, including osteoblasts, vascular endothelia, perivascular mesenchymal cells and HSC progeny cells, function conjunctively as niche cells to regulate HSCs.
The study of HSC niche cells and their functions provides insights into stem cell biology and also may be extrapolated into the study of cancer stem cells. This article is part of a Special Issue entitled Biochemistry of Stem Cells.
骨髓造血干细胞（HSC）龛为HSC的调控提供了一个特殊的微环境。龛对HSC的严格控制协调了HSC增殖与分化之间的平衡，以维持稳态及应激造血过程中血液系统的平衡。成骨龛和血管龛是经典确定的骨髓龛组成部分。
近期研究拓宽了我们对骨髓龛的理解，即其为骨髓内多种龛细胞的集合。我们对HSC龛进行概述，旨在描述已明确的以及可能存在的龛细胞间相互作用，这些相互作用共同调节HSC的完整性。
骨髓中的多种细胞，包括成骨细胞、血管内皮细胞、血管周围间充质细胞和HSC子代细胞，共同作为龛细胞发挥功能以调节HSC。
对HSC龛细胞及其功能的研究为干细胞生物学提供了见解，也可能推广至癌症干细胞的研究。本文是名为“干细胞生物化学”特刊的一部分。
