Integrated Department of Immunology, University of Colorado School of Medicine, Denver, CO, USA.
Immunol Res. 2013 Mar;55(1-3):178-86. doi: 10.1007/s12026-012-8359-6.
Pulmonary dendritic cells (DCs) constantly sample the tissue and traffic inhaled antigens to the lung-draining lymph node where they normally orchestrate an appropriate immune response. The dynamic ability of these professional antigen-presenting cells to promote tolerance or immunity has been intensively studied by several groups, including ours. Distinct DC subsets in both lymphoid and non-lymphoid tissues have been described based on their surface molecule expression and location. Current efforts to unravel DC development and function are providing insight into the various roles each subset offers the immune system. Elucidating DC functions, particularly in the lung, may then allow use of the inherent ability of these cells for enhanced vaccine strategies and therapeutics for pulmonary infections and diseases.
肺树突状细胞（DCs）不断地对组织进行采样，并将吸入的抗原运送到肺引流淋巴结，在那里它们通常协调适当的免疫反应。这些专业抗原呈递细胞促进耐受或免疫的动态能力已经被包括我们在内的几个研究小组进行了深入研究。根据其表面分子表达和位置，已经描述了淋巴组织和非淋巴组织中的不同 DC 亚群。目前，人们正在努力揭示 DC 的发育和功能，这为了解每个亚群为免疫系统提供的各种作用提供了线索。阐明 DC 的功能，特别是在肺部，可能会使这些细胞的固有能力得到增强，从而用于肺部感染和疾病的疫苗策略和治疗。
