Department of Ophthalmology, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan.
Invest Ophthalmol Vis Sci. 2012 Oct 3;53(11):6770-5. doi: 10.1167/iovs.12-9683.
To investigate the relationship between the severity of metamorphopsia and the foveal microstructure measured with spectral-domain optical coherence tomography (SD-OCT) in patients with epiretinal membrane (ERM).
This study included 48 eyes of 48 patients with idiopathic ERM and 18 age-matched normal controls. We examined the logarithm of the minimum angle of resolution best-corrected visual acuity (logMAR BCVA) and the severity of metamorphopsia using M-CHARTS. Central foveal thickness (CFT), central retinal thickness at the fovea (CRT-1mm) and parafovea (CRT-3mm), and macular volume (MV) were measured with SD-OCT software. Based on the obtained OCT image, we divided the 1.0 × 1.0-mm area centered on the fovea into nine sections and quantified the following parameters using an image-processing program: mean thickness of the ganglion cell layer (GCL), inner nuclear layer (INL), and outer retinal layer (ONL+OPL: outer nuclear layer and outer plexiform layer), the degree of the photoreceptor inner and outer segment junction (IS/OS), and external limiting membrane (ELM) disruption.
CFT, CRT-1mm, CRT-3mm, MV, mean GCL, INL, and ONL+OPL thickness were significantly larger in patients with ERM than in normal controls. Multiple regression analysis revealed that the severity of metamorphopsia was significantly related to the mean INL thickness (P < 0.0001). LogMAR BCVA had a significant correlation with the degree of IS/OS disruption (P < 0.05), whereas other parameters were not relevant.
In patients with idiopathic ERM, the degree of metamorphopsia is associated with INL thickness, and IS/OS status influences visual acuity.
研究特发性视网膜前膜（ERM）患者黄斑区微结构与光相干断层扫描（SD-OCT）测量的周边像差严重程度的关系。
本研究纳入 48 例特发性 ERM 患者（48 只眼）和 18 名年龄匹配的正常对照者。我们使用 M-CHARTS 检查了最小分辨角对数视力（logMAR BCVA）和周边像差的严重程度。使用 SD-OCT 软件测量了中心视网膜厚度（CFT）、黄斑中心凹视网膜厚度（CRT-1mm）、黄斑中心凹旁视网膜厚度（CRT-3mm）和黄斑区体积（MV）。基于所获得的 OCT 图像，我们将以黄斑为中心的 1.0×1.0mm 区域分为 9 个部分，并使用图像处理程序对以下参数进行量化：神经节细胞层（GCL）、内核层（INL）和外视网膜层（ONL+OPL：外核层和外丛状层）的平均厚度、光感受器内外节连接（IS/OS）的程度以及外界膜（ELM）的中断。
ERM 患者的 CFT、CRT-1mm、CRT-3mm、MV、平均 GCL、INL 和 ONL+OPL 厚度均显著大于对照组。多元回归分析显示，周边像差的严重程度与平均 INL 厚度显著相关（P<0.0001）。logMAR BCVA 与 IS/OS 中断程度显著相关（P<0.05），而其他参数则无相关性。
在特发性 ERM 患者中，周边像差的程度与 INL 厚度有关，IS/OS 状态影响视力。
