Karinen Heikki M, Uusitalo Arja, Vähä-Ypyä Henri, Kähönen Mika, Peltonen Juha E, Stein Phyllis K, Viik Jari, Tikkanen Heikki O
Unit for Occupational Health, Department of Health Sciences, University of Tampere Tampere, Finland.
Front Physiol. 2012 Aug 30;3:336. doi: 10.3389/fphys.2012.00336. eCollection 2012.
If the body fails to acclimatize at high altitude, acute mountain sickness (AMS) may result. For the early detection of AMS, changes in cardiac autonomic function measured by heart rate variability (HRV) may be more sensitive than clinical symptoms alone. The purpose of this study was to ascertain if the changes in HRV during ascent are related to AMS.
We followed Lake Louise Score (LLS), arterial oxygen saturation at rest (R-SpO(2)) and exercise (Ex-SpO(2)) and HRV parameters daily in 36 different healthy climbers ascending from 2400 m to 6300 m altitudes during five different expeditions.
After an ascent to 2400 m, root mean square successive differences, high-frequency power (HF(2 min)) of HRV were 17-51% and Ex-SpO(2) was 3% lower in those climbers who suffered from AMS at 3000 to 4300 m than in those only developing AMS later (≥5000 m) or not at all (all p < 0.01). At the altitude of 2400 m RMSSD(2 min) ≤ 30 ms and Ex-SpO(2) ≤ 91% both had 92% sensitivity for AMS if ascent continued without extra acclimatization days.
Changes in supine HRV parameters at 2400 m were related to AMS at 3000-4300 m Thus, analyses of HRV could offer potential markers for identifying the climbers at risk for AMS.
如果身体在高海拔地区未能适应，可能会导致急性高原病（AMS）。对于AMS的早期检测，通过心率变异性（HRV）测量的心脏自主神经功能变化可能比单独的临床症状更敏感。本研究的目的是确定上升过程中HRV的变化是否与AMS有关。
在五次不同的探险中，我们每天跟踪36名从2400米上升到6300米海拔的不同健康登山者的路易斯湖评分（LLS）、静息动脉血氧饱和度（R-SpO₂）和运动时动脉血氧饱和度（Ex-SpO₂）以及HRV参数。
上升到2400米后，那些在3000至4300米患AMS的登山者的HRV的均方根连续差值、高频功率（HF₂min）比那些后来才患AMS（≥5000米）或根本未患AMS的登山者低17 - 51%，Ex-SpO₂低3%（所有p < 0.01）。在2400米海拔时，如果继续上升且没有额外的适应天数，RMSSD₂min≤30毫秒和Ex-SpO₂≤91%对AMS的敏感度均为92%。
2400米时仰卧位HRV参数的变化与3000 - 4300米处的AMS有关。因此，HRV分析可为识别有AMS风险的登山者提供潜在指标。
