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辣木发酵清麴对 KK-A(y)糖尿病小鼠的抗糖尿病作用。

Antidiabetic Effect of Morinda citrifolia (Noni) Fermented by Cheonggukjang in KK-A(y) Diabetic Mice.

机构信息

Fermentation and Functionality Research Group, Korea Food Research Institute, Gyeonggi-Do, Sungnam-Si 463-746, Republic of Korea.

出版信息

Evid Based Complement Alternat Med. 2012;2012:163280. doi: 10.1155/2012/163280. Epub 2012 Aug 27.

DOI:10.1155/2012/163280
PMID:22969823
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3434424/
Abstract

Antidiabetic effects of Morinda citrifolia (aka Noni) fermented by Cheonggukjang (fast-fermented soybean paste) were evaluated using a T2DM (type 2 diabetes mellitus) murine model. Six-week-old KK-Ay/TaJcl mice were randomly divided into four groups: (1) the diabetic control (DC) group, provided with a normal mouse diet; (2) the positive control (PC) group, provided with a functional health food diet; (3) the M. citrifolia (MC) group, provided with an MC-based diet; (4) the fermented M. citrifolia (FMC) group, provided with an FMC-based diet. Over a testing period of 90 days, food and water intake decreased significantly in the FMC and PC groups compared with the DC group. Blood glucose levels in the FMC group were 211.60-252.20 mg/dL after 90 days, while those in the control group were over 400 mg/dL after 20 days. In addition, FMC supplementation reduced glycosylated hemoglobin (HbA1c) levels, enhanced insulin sensitivity, and significantly decreased serum triglycerides and low-density lipoprotein (LDL) cholesterol. Furthermore, a fermented M. citrifolia 70% ethanolic extract (FMCE) activated peroxisome proliferator-activated receptor-(PPAR-) γ and stimulated glucose uptake via stimulation of AMP-activated protein kinase (AMPK) in cultured C2C12 cells. These results suggest that FMC can be employed as a functional health food for T2DM management.

摘要

利用 T2DM（2 型糖尿病）鼠模型评价了由清麴（快速发酵的大豆酱）发酵的诺丽果（Morinda citrifolia）的抗糖尿病作用。将 6 周龄 KK-Ay/TaJcl 小鼠随机分为四组：（1）糖尿病对照组（DC），给予正常鼠饲料；（2）阳性对照组（PC），给予功能性保健食品饲料；（3）诺丽果组（MC），给予基于诺丽果的饲料；（4）发酵诺丽果组（FMC），给予基于发酵诺丽果的饲料。在 90 天的测试期内，与 DC 组相比，FMC 和 PC 组的食物和水摄入量显著减少。FMC 组 90 天后的血糖水平为 211.60-252.20mg/dL，而对照组 20 天后血糖水平超过 400mg/dL。此外，FMC 补充剂降低了糖化血红蛋白（HbA1c）水平，增强了胰岛素敏感性，并显著降低了血清甘油三酯和低密度脂蛋白（LDL）胆固醇。此外，发酵的诺丽果 70%乙醇提取物（FMCE）激活过氧化物酶体增殖物激活受体-γ（PPAR-γ），并通过刺激 AMP 激活的蛋白激酶（AMPK）刺激培养的 C2C12 细胞中的葡萄糖摄取。这些结果表明，FMC 可作为 2 型糖尿病管理的功能性保健食品。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2be3/3434424/ae9cea637124/ECAM2012-163280.009.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2be3/3434424/049e5b78868f/ECAM2012-163280.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2be3/3434424/ae9cea637124/ECAM2012-163280.009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2be3/3434424/57fbd2ab825a/ECAM2012-163280.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2be3/3434424/130a089d98bb/ECAM2012-163280.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2be3/3434424/a3dd69a6de25/ECAM2012-163280.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2be3/3434424/34d5f7302d88/ECAM2012-163280.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2be3/3434424/0590184311f1/ECAM2012-163280.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2be3/3434424/25b4501bd64a/ECAM2012-163280.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2be3/3434424/24d06ee6b891/ECAM2012-163280.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2be3/3434424/049e5b78868f/ECAM2012-163280.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2be3/3434424/ae9cea637124/ECAM2012-163280.009.jpg

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