For reprints and all correspondence: Tel: +91-532-2641157; 2462125; E-mail:
Evid Based Complement Alternat Med. 2008 Dec;5(4):415-20. doi: 10.1093/ecam/nem044. Epub 2007 May 17.
The present study is an extension of our previous work carried out on Cynodon dactylon. This study deals with the critical evaluation of glycemic potential of ethanolic extract of defatted C. dactylon. The doses of 250, 500 and 750 mg kg(-1) bw of the extract were administered orally to normal as well as Streptozotocin-induced diabetic rats to study its glycemic potential. The effect of repeated oral administration of the same doses of ethanolic extract was also studied on serum lipid profile of severely diabetic (SD) rats. The dose of 500 mg kg(-1) bw was identified as the most effective dose as it lowered the blood glucose levels of normal by 42.12% and of diabetic by 43.42% during fasting blood glucose (FBG) and glucose tolerance test respectively. The SD rats were also treated daily with this identified dose of 500 mg kg(-1) bw for 2 weeks and a significant reduction of 56.34% was observed in FBG level. Total cholesterol, low density lipoprotein and triglyceride levels were also decreased by 32.94, 64.06 and 48.46% respectively in SD rats whereas, cardioprotective high density lipoprotein increased by 16.45%. The reduced urine sugar level and increased body weight are additional advantages. These evidences clearly indicate that the ethanolic extract of defatted C. dactylon has high antidiabetic potential along with good hypolipidemic profile.
本研究是对我们之前关于狗牙根的工作的延伸。这项研究涉及对脱脂狗牙根的乙醇提取物的血糖生成潜力的临界评价。以 250、500 和 750mgkg(-1)bw 的剂量对正常和链脲佐菌素诱导的糖尿病大鼠进行口服给药，以研究其血糖生成潜力。还研究了相同剂量的乙醇提取物重复口服给药对严重糖尿病（SD）大鼠血清脂质谱的影响。确定 500mgkg(-1)bw 的剂量为最有效剂量，因为它在空腹血糖（FBG）和葡萄糖耐量试验中分别使正常大鼠的血糖水平降低了 42.12%和 43.42%，使糖尿病大鼠的血糖水平降低了 43.42%。SD 大鼠也每天用 500mgkg(-1)bw 的这个确定剂量治疗 2 周，FBG 水平显著降低了 56.34%。总胆固醇、低密度脂蛋白和甘油三酯水平分别降低了 32.94%、64.06%和 48.46%，而保护性高密度脂蛋白增加了 16.45%。尿糖水平降低和体重增加是额外的优势。这些证据清楚地表明，脱脂狗牙根的乙醇提取物具有很高的降血糖潜力，同时具有良好的降血脂谱。
