大鼠二乙基亚硝胺诱导肝癌发生的序贯分析。
Sequential analysis of diethylnitrosamine-induced hepatocarcinogenesis in rats.
作者信息
Abe Ryo, Okano Jun-Ichi, Imamoto Ryu, Fujise Yuki, Murawaki Yoshikazu
机构信息
Second Department of Internal Medicine, Tottori University School of Medicine, Yonago, Tottori 683-8504, Japan.
出版信息
Exp Ther Med. 2012 Mar;3(3):371-378. doi: 10.3892/etm.2011.419. Epub 2011 Dec 15.
Abstract
In the present study, we examined the sequential changes of diethylnitrosamine (DEN)-induced hepatocarcinogenesis in Wistar rats. After 14 weeks of DEN treatment, hyperplastic nodules developed as a consequence of the appearance of renewed hepatocytes, degenerated hepatocytes, oval cells and fibrotic changes. Total bilirubin and alanine aminotransferase levels were significantly higher in the DEN group compared to the control group throughout the experimental period. Our data may prove beneficial to future analyses of chemopreventive compounds during various stages of hepatocarcinogenesis in rats.
摘要
在本研究中，我们检测了二乙基亚硝胺（DEN）诱导的Wistar大鼠肝癌发生过程中的一系列变化。给予DEN处理14周后，由于新生肝细胞、变性肝细胞、卵圆细胞的出现以及纤维化改变，形成了增生性结节。在整个实验期间，DEN组的总胆红素和丙氨酸转氨酶水平显著高于对照组。我们的数据可能对未来大鼠肝癌发生不同阶段化学预防化合物的分析有益。
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