Palomo Iván, Fuentes Eduardo, Padró Teresa, Badimon Lina
Department of Clinical Biochemistry and Immunohematology, Faculty of Health Sciences, University of Talca;
Exp Ther Med. 2012 Apr;3(4):577-584. doi: 10.3892/etm.2012.477. Epub 2012 Feb 9.
In recent years, it has been shown that platelets are not only involved in the arterial thrombotic process, but also that they play an active role in the inflammatory process of atherogenesis from the beginning. The interaction between platelets and endothelial cells occurs in two manners: activated platelets unite with intact endothelial cells, or platelets in resting adhere to activated endothelium. In this context, inhibition of the platelet function (adhesion/aggregation) could contribute to the prevention of atherothrombosis, the leading cause of cardiovascular morbidity. This can be achieved with antiplatelet agents. However, at the public health level, the level of primary prevention, a healthy diet has also been shown to exert beneficial effects. Among those elements of a healthy diet, the consumption of tomatoes (Solanum lycopersicum L.) stands out for its effect on platelet anti-aggregation activity and endothelial protection, which may be beneficial for cardiovascular health. This article briefly discusses the involvement of platelets in atherogenesis and the possible mechanisms of action provided by tomatoes for platelet anti-aggregation activity and endothelial protection.
近年来，研究表明血小板不仅参与动脉血栓形成过程，而且从一开始就在动脉粥样硬化的炎症过程中发挥积极作用。血小板与内皮细胞之间的相互作用以两种方式发生：活化的血小板与完整的内皮细胞结合，或者静息状态的血小板黏附于活化的内皮。在这种情况下，抑制血小板功能（黏附/聚集）可能有助于预防动脉粥样硬化血栓形成，而动脉粥样硬化血栓形成是心血管疾病发病的主要原因。这可以通过抗血小板药物来实现。然而，在公共卫生层面的一级预防中，健康饮食也已显示出有益效果。在健康饮食的这些要素中，食用番茄（Solanum lycopersicum L.）因其对血小板抗聚集活性和内皮保护的作用而脱颖而出，这可能对心血管健康有益。本文简要讨论血小板在动脉粥样硬化形成中的作用以及番茄对血小板抗聚集活性和内皮保护的可能作用机制。
