Ban Ju Yeon, Kang Sung Wook, Lee Jong Seok, Chung Joo-Ho, Ko Young Gwan, Choi Han Sung
Department of Pharmacology, College of Dentistry, Dankook University, Cheonan;
Exp Ther Med. 2012 Apr;3(4):693-698. doi: 10.3892/etm.2012.449. Epub 2012 Jan 11.
In the present study, we investigated the neuroprotective effect of Korean red ginseng (KRG) following focal brain ischemia/reperfusion injury, in relation to its antioxidant activities. The middle cerebral artery occlusion/reperfusion (MCAO/R) model in rats was employed. The KRG extract (100 mg/kg, perorally) was administered once daily for 7 days following MCAO/R. The elevated levels of lipid peroxidation in the MCAO/R group were attenuated significantly in the KRG-administered group. The significantly depleted activity of the antioxidant enzymes glutathione peroxidase, superoxide dismutase and catalase was prevented in the KRG-administered group. In the neurobehavioral evaluation expressed as the modified neurological severity score and corner-turn test, the daily intake of KRG showed consistent and significant improvement in the neurological deficits for 7 days following MCAO/R injury. These results indicate that KRG has a neuroprotective effect against ischemia/reperfusion brain injury by reducing the level of lipid peroxidation and increasing the endogenous antioxidant enzymatic activity.
在本研究中，我们研究了韩国红参（KRG）在局灶性脑缺血/再灌注损伤后与其抗氧化活性相关的神经保护作用。采用大鼠大脑中动脉闭塞/再灌注（MCAO/R）模型。在MCAO/R后，每天口服一次KRG提取物（100mg/kg），持续7天。在给予KRG的组中，MCAO/R组脂质过氧化水平的升高得到显著减轻。给予KRG的组中，抗氧化酶谷胱甘肽过氧化物酶、超氧化物歧化酶和过氧化氢酶显著降低的活性得到了预防。在以改良神经功能缺损评分和转角试验表示的神经行为评估中，MCAO/R损伤后7天，每日摄入KRG显示神经功能缺损持续且显著改善。这些结果表明，KRG通过降低脂质过氧化水平和增加内源性抗氧化酶活性，对缺血/再灌注脑损伤具有神经保护作用。
