Jack A S, Boylston A W, Carrel S, Grigor I
Pathology Department, Leeds University, England.
Am J Pathol. 1990 Jan;136(1):17-21.
Monoclonal antibodies that recognize the proteins specified by two families of T-cell antigen receptor variable region genes were assessed as clonal markers in cutaneous T-cell lymphoma (mycosis fungoides and Sezary syndrome). About 3% to 5% of tumors were expected to react with each antibody. However, 10 of 16 cases studied reacted with MAbs specific for the V beta 8 gene family. All the positive cases were examples of the plaque or tumor stages of CTCL. None of the cases of eczematoid or premycotic CTCL showed uniform reactivity with these antibodies. Unexpected use of one particular V gene family raises the possibility that CTCL derives from a distinct subpopulation of antigen- or virus-selected T cells.
在皮肤T细胞淋巴瘤（蕈样肉芽肿和塞扎里综合征）中，评估了识别两个T细胞抗原受体可变区基因家族所指定蛋白质的单克隆抗体作为克隆标志物。预计约3%至5%的肿瘤会与每种抗体发生反应。然而，在研究的16例病例中，有10例与Vβ8基因家族特异性单克隆抗体发生反应。所有阳性病例均为皮肤T细胞淋巴瘤斑块期或肿瘤期的实例。湿疹样或蕈样前期皮肤T细胞淋巴瘤病例均未显示与这些抗体有一致的反应性。一个特定V基因家族的意外使用增加了皮肤T细胞淋巴瘤源自抗原或病毒选择的T细胞的独特亚群的可能性。
