Groene Hart Ziekenhuis, Gouda, The Netherlands.
Acta Neurol Scand. 2013 May;127(5):301-8. doi: 10.1111/ane.12007. Epub 2012 Sep 12.
Patients with multiple sclerosis (MS) are more frequently born in spring when compared to autumn. Fluctuation of UV-light has been hypothesized to drive this phenomenon.
To assess the correlation between fluctuation of sunlight and birth season in persons with MS.
For this record-linkage study, we collected from the international MSBase and the Italian MS iMed-web databases the dates of birth of 11,415 patients with MS from 36 centres from 15 countries worldwide and compared these to dates of live-births from national registries. From all participating sites, we collected data on UV-light fluctuation and assessed its correlation with seasonal fluctuation in MS births.
Compared with the reference cohort, an increased proportion of persons with MS were born in spring and a decreased proportion in autumn (odds ratio (OR) to be born in spring versus autumn = 1.158, χ² = 36.347, P < 0.001). There was no significantly increased fluctuation of MS births with increased quartile of ambient UV-light fluctuation (Ptrend = 0.086).
Seasonal fluctuation of MS births as found in this worldwide cohort of patients with MS did not correlate with variation in seasonal fluctuation of UV-light. Most likely, it results from a complex interplay between fluctuation of sunlight, behavioural factors, other environmental factors and (epi)genetic factors.
与秋季相比，多发性硬化症（MS）患者更多地出生在春季。有人假设，紫外线的波动会导致这种现象。
评估阳光波动与多发性硬化症患者出生季节之间的相关性。
在这项基于记录的关联研究中，我们从国际 MSBase 和意大利 MS iMed-web 数据库中收集了来自全球 15 个国家 36 个中心的 11415 名多发性硬化症患者的出生日期，并将这些出生日期与国家登记处的实际出生日期进行了比较。我们从所有参与的地点收集了有关紫外线波动的数据，并评估了其与多发性硬化症出生季节性波动的相关性。
与参考队列相比，多发性硬化症患者中出生在春季的比例增加，而出生在秋季的比例减少（与秋季相比，出生在春季的几率为 1.158，χ²=36.347，P<0.001）。随着环境紫外线波动的四分位增加，多发性硬化症出生的波动没有显著增加（Ptrend=0.086）。
在这个全球多发性硬化症患者队列中发现的多发性硬化症出生的季节性波动与紫外线季节性波动的变化没有相关性。最有可能的是，它是由阳光波动、行为因素、其他环境因素和（表观）遗传因素之间的复杂相互作用产生的。
