Dobrakowski Paweł, Bogocz Michał, Cholewa Kamil, Rajchel Mateusz, Kapica-Topczewska Katarzyna, Wawrzyniak Sławomir, Bartosik-Psujek Halina, Kułakowska Alina, Koziarska Dorota, Adamczyk-Sowa Monika
Department of Neurology in Zabrze, Medical University of Silesia, Zabrze, Poland.
Department of Neurology, Medical University of Białystok, Białystok, Poland.
PLoS One. 2017 Apr 6;12(4):e0175156. doi: 10.1371/journal.pone.0175156. eCollection 2017.
Many studies have shown that people born in the spring are at a higher risk of developing multiple sclerosis (MS). This may be associated with lower levels of sun exposure, and consequently, lower levels of vitamin D3 during pregnancy. However, these relationships have not been verified thus far in any countries in Central Europe.
The aim of our study was to determine the frequency distribution of births for each calendar month in patients suffering from MS in Poland.
We analyzed data for 2574 patients diagnosed with MS (1758 women, 816 men) living in Poland for an extended period. We added corrections resulting from the frequency distribution of births for the years in which the patients were born. We applied the Hewitt test for seasonality with Rogerson modification for 3-, 4-, or 6-month pulses or periods. Moreover, we examined the average number hours of sunshine in every month of the year.
The rank-sums for successive 3- and 4-month segments indicated the period from September to December and from October to December as having a significantly lower incidence (p = 0.027 and p = 0.054, respectively). We did not find a correlation between with hours of sunshine in the first trimester of pregnancy, the child's birth month, and the child developing MS.
We were able to confirm a seasonal variation in the risk of MS in Poland. However, these findings did not correlate with hours of sunshine during the first trimester of pregnancy.
许多研究表明，春季出生的人患多发性硬化症（MS）的风险更高。这可能与孕期日照时间较短以及相应的维生素D3水平较低有关。然而，到目前为止，在中欧的任何国家都尚未证实这些关系。
我们研究的目的是确定波兰多发性硬化症患者每个日历月的出生频率分布。
我们分析了长期居住在波兰的2574例被诊断为多发性硬化症患者（1758名女性，816名男性）的数据。我们对患者出生年份的出生频率分布进行了校正。我们应用了经罗杰森修正的休伊特季节性检验，用于3个月、4个月或6个月的时间段。此外，我们还研究了一年中每个月的平均日照小时数。
连续3个月和4个月时间段的秩和表明，9月至12月以及10月至12月的发病率显著较低（分别为p = 0.027和p = 0.054）。我们未发现孕期头三个月的日照小时数、孩子的出生月份与孩子患多发性硬化症之间存在相关性。
我们能够证实在波兰多发性硬化症风险存在季节性变化。然而，这些发现与孕期头三个月的日照小时数并无关联。
