Department of Dermatology, Memorial Sloan-Kettering Cancer Center, New York, NY 10022, USA.
Photodermatol Photoimmunol Photomed. 2012 Oct;28(5):228-34. doi: 10.1111/j.1600-0781.2012.00674.x.
Endogenous production and ultraviolet-generated free radicals in the skin can lead to photoaging and even skin cancer. Topical antioxidants have been found to provide benefits against ultraviolet damage and these ingredients have been incorporated into various cosmetic products and claimed to have substantial effects. Currently, there is a lack in a standardized rating system to measure the concentration and activity levels of antioxidants in these products. As a result, it is difficult for consumers and clinicians to evaluate and select commercial products based on readily accessible evidence. In this review, we will describe four assays which have been used to measure antioxidants in various products, and the strengths and weaknesses of each test will be detailed. We will highlight key considerations for clinicians when interpreting the results of antioxidant tests when evaluating commercial products containing antioxidants.
内源性产生的以及紫外线产生的自由基会导致皮肤光老化，甚至皮肤癌。人们发现局部抗氧化剂可以预防紫外线损伤，这些成分已经被应用于各种化妆品，并宣称有显著的效果。目前，还没有标准化的评分系统来衡量这些产品中抗氧化剂的浓度和活性水平。因此，消费者和临床医生很难根据现成的证据来评估和选择商业产品。在这篇综述中，我们将描述四种已用于测量各种产品中抗氧化剂的方法，并详细介绍每种测试的优缺点。我们将强调在评估含有抗氧化剂的商业产品时，临床医生在解释抗氧化剂测试结果时需要考虑的关键因素。
